Tracer library / [18F]fluoro-2-deoxy-D-galactose
[18F]fluoro-2-deoxy-D-galactose
Also written as [18F]fluoro-2-deoxy-D-galactose; [F-18]fluoro-2-deoxy-D-galactose
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 2
What it is
- Compound class
- Radiolabelled galactose analogue (fluorinated monosaccharide PET tracer)
- Target / mechanism
- —
- Clinical application
- PET imaging of regional liver metabolic function, including liver cirrhosis and liver disease treatment evaluation PMID 21531284
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab MX GE HealthCare | vendor cassette | none | 3.8±1.2% decay-corrected | 98±1% | Talose triflate…Talose triflate (1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-talopyranose) ABX | 21531284 2011 Nucl Med Biol The radiofluorination was performed in the commercially available system TRACERlab MX (GEMS, Uppsala, Sweden) including basic hydrolysis. - The radiochemical yield of the transformation of Talose triflate into FDGal by the present method was hence limited to 3.8±1.2% (decay corrected; 42 productions). |
| TRACERlab MX GE HealthCare | vendor cassette | none | 3.8±1.2% decay-corrected | 98±1% | Talose triflate…Talose triflate (1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-talopyranose) ABX | 21531284 2011 Nucl Med Biol The synthesis could also be performed in the FDG Microlab (GEMS, Uppsala, Sweden) with acidic hydrolysis. - Experimental variations in reaction temperature (60–85°C), duration (2–10 min), phase transfer catalyst (Kryptofix 2.2.2./K2CO3, tetrabutylammoiumhydrogen carbonate), hydrolysis conditions (1 M HCl, 20 min, 100°C or 2 M NaOH, 2 min, room temperature), or synthesizer (TRACERlab MX or FDG Microlab) did not affect the radiochemical yield. |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- ABX
- Typical final purification
- —
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); weak UV chromophore (sugar/simple ion/short-chain acid) -> conductometric detection (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]fluoro-2-deoxy-D-galactose.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with F-18.