Tracer library / [18F]Florbetaben
Structure of Florbetaben (unlabelled parent compound, from PubChem)
Unlabelled parent compoundPubChem CID 53257383

[18F]Florbetaben

Also written as [18F]Florbetaben; [F-18]Florbetaben; Florbetaben
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
Approved
Syntheses indexed
1
Cardiac amyloidosisAlzheimer's diseaseAmyloid pathology

What it is

Compound class
18F-labeled amyloid PET radiotracer (stilbene derivative)
Target / mechanism
Fibrillar amyloid-β plaque PMID 42720909
Clinical application
Alzheimer's disease pathology across the clinical continuum, from preclinical stages to overt dementia PMID 42720909
Theranostic pair
—

Regulatory status

FDA
Yes — 2014; Neuraceq (florbetaben F-18); sponsor LANTHEUS; NDA 204677 Drugs@FDA / openFDA drug registry, NDA 204677, original approval 2014-03-19, marketing status 'Prescription' — https://api.fda.gov/drug/drugsfda.json?search=application_number:%22NDA204677%22 (queried 2026-09-18)
EMA (centralised)
Yes — 2014; Neuraceq (florbetaben (18F)); Lantheus Germany GmbH; EMEA/H/C/002553 EMA medicines register (JSON export 2026-09-18), EPAR Neuraceq: status 'Authorised', marketing authorisation date 2014-02-20 — https://www.ema.europa.eu/en/medicines/human/EPAR/neuraceq
Other approvals
—
Brand names
—

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
PET-MF-2V-IT-1
vendor not confirmed -- see article
—HPLC20-25%
not corrected
>95%methanesulfonic acid…methanesulfonic acid 2-[2-(2-{4-[2-(4-methylamino-phenyl)-vinyl]-phenoxy}-ethoxy)-ethoxy]-ethyl ester23085550
2013 Appl Radiat Isot
using the commercial PET-MF-2V-IT-1 synthesizer - 20-25% yield (uncorrected for decay)

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph
not verified No Ph. Eur. check is recorded for this entry.
USP monograph
not verified No USP check is recorded for this entry.
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with F-18.
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