Tracers / [18F]Florbetaben
[18F]Florbetaben
Also written as [18F]Florbetaben; [F-18]Florbetaben; Florbetaben
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- approved
- Syntheses indexed
- 2
What it is
- Compound class
- 18F-labeled amyloid PET radiotracer (stilbene derivative)
- Target / mechanism
- Fibrillar amyloid-β plaque PMID 42720909
- Clinical application
- Alzheimer's disease pathology across the clinical continuum, from preclinical stages to overt dementia PMID 42720909
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | HPLC | 20-25% no | >95% | methanesulfonic acid 2-[2-(2-{4-[2-(4-methylamino-phenyl)-vinyl]-phenoxy}-ethoxy)-ethoxy]-ethyl ester | 23085550 2013 Appl Radiat Isot using the commercial PET-MF-2V-IT-1 synthesizer — 20-25% yield (uncorrected for decay) |
| — | — | — | — | — | — | 42142951 2026 J Nucl Cardiol |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]Florbetaben.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with F-18.