Tracers / [18F]FBnTP
[18F]FBnTP
Also written as [18F]FBnTP; [F-18]FBnTP
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 2
What it is
- Compound class
- lipophilic phosphonium cation (triphenylphosphonium derivative)
- Target / mechanism
- Mitochondrial membrane potential sensor; cellular uptake correlated with mitochondrial oxidative phosphorylation PMID 38935218
- Clinical application
- Imaging of myocardial perfusion, coronary artery stenosis severity, ischemic area delineation, apoptosis detection/quantification, and oncological diagnosis and therapeutic monitoring PMID 38935218
- Theranostic pair
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Regulatory status
- FDA
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- EMA (centralised)
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- Other approvals
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- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| ELIXYS FLEX/CHEM Sofie Biosciences | vendor cassette | SPE | 28.6 ± 5.1 % yes | > 99 % | 4-trimethylammoniumbenzaldehyde trifluoromethanesulfonate ABX | 28905308 2018 Mol Imaging Biol a three-pot, four-step synthesis was implemented on the ELIXYS FLEX/CHEM radiosynthesizer (Sofie Biosciences) — RCY = 28.6 ± 5.1 % with n = 3 |
| TRACERlab FX FN GE HealthCare | custom manifold | HPLC+SPE | 28.33 ± 13.92% no | 99.79 ± 0.41% | triphenyl(4‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)benzyl)phosphonium trifluoromethanesulfonate MilliporeSigma | 38935218 2024 EJNMMI Radiopharm Chem GE TRACERlab™ FXFN, the most widely used synthesis module for routine clinical radiopharmaceutical production — radiochemical yields ranging from 28.33 ± 13.92% (non-decay corrected) |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FBnTP.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with F-18.