Tracers / [18F]FB-IL2

[18F]FB-IL2

Also written as [18F]FB-IL-2; [18F]FB-IL2; [F-18]FB-IL-2; [F-18]FB-IL2; N-(4-[18F]fluorobenzoyl)-interleukin-2
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
—
Syntheses indexed
1
Immune cell and immunotherapy imaging

What it is

Compound class
18F-labeled interleukin-2 protein (radiolabeled cytokine, IL2 conjugated with N-succinimidyl 4-[18F]fluorobenzoate)
Target / mechanism
Targets interleukin-2 (IL2) receptors on activated T-cells PMID 31659562
Clinical application
PET imaging of activated T-cells in humans for inflammatory diseases and oncology PMID 31659562
Theranostic pair
—

Regulatory status

FDA
—
EMA (centralised)
—
Other approvals
—
Brand names
—

Clinical use

Typical injected activity
—
Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
Modular-Lab PharmTracer
Eckert & Ziegler
vendor cassetteSPE3-4%97.1%ethyl 4-(trimethylammonium)benzoate triflate salt
ABX
31659562
2019 EJNMMI Radiopharm Chem
A Modular-Lab PharmTracer Eckert & Ziegler synthesis module (4-fold and 6-fold cassette) was used for the GMP compliant design of the production method of [18F]SFB and [18F]FB-IL2. — The radiochemical yield of [18F]FB-IL2 was 3–4%, based on the amount of [18F]SFB used.

Need this precursor?We can point you to suppliers for [18F]FB-IL2, or handle the enquiry for you.

Get in touch

Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
—
USP monograph
—
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

Setting up quality control?We can help you scope the equipment needed to release [18F]FB-IL2.

Get in touch

Notes

Added from reverse module search (stage 6); 2 article(s) with F-18.