Tracer library / [18F]FB-HER2
[18F]FB-HER2
Also written as [18F]FB-HER2; [F-18]FB-HER2
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 2
What it is
- Compound class
- HER2-targeting single-domain antibody (sdAb) labeled via N-succinimidyl-4-[18F]fluorobenzoate
- Target / mechanism
- Human Epidermal Growth Factor Receptor 2 (HER2) PMID 39542993
- Clinical application
- HER2 PET/CT imaging for quantifying HER2 expression to guide clinical decision making, evaluated in HER2-positive tumours PMID 39542993
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| AllinOne (AiO) Trasis | vendor cassette | SPE | 14 ± 2% decay-corrected | >95% | N-succinimidyl-4-[18F]fluorobenzoate…N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) and HER2 sdAb Abscint NV | 39542993 2024 EJNMMI Radiopharm Chem were produced on an AllinOne® (AiO) synthesizer (Trasis) with 36 rotors, 5 syringe actuators and 1 heater, using disposable single-use cassettes - has an overall RCY d.c. of 14 ± 2% (n = 4) |
| AllinOne (AiO) Trasis | vendor cassette | SPE | 8 ± 1% decay-corrected | >95% | N-succinimidyl-4-[18F]fluorobenzoate…N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) and HER2 sdAb Abscint NV | 39542993 2024 EJNMMI Radiopharm Chem were produced on an AllinOne® (AiO) synthesizer (Trasis) with 36 rotors, 5 syringe actuators and 1 heater, using disposable single-use cassettes - the complete automated production of [18F]FB-HER2 sdAb has an overall RCY d.c. of 8 ± 1% (n = 4) |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- Abscint NV
- Typical final purification
- —
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FB-HER2.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 39542993: 'N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) and HER2 sdAb'.