Tracers / [18F]FB-A20FMDV2
[18F]FB-A20FMDV2
Also written as [18F]FB-A20FMDV2; [F-18]FB-A20FMDV2
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- preclinical study
- Syntheses indexed
- 1
What it is
- Compound class
- Radiolabelled peptide (RGD-containing integrin-binding peptide, A20FMDV2, conjugated to 4-[18F]fluorobenzoic acid prosthetic group)
- Target / mechanism
- Binds selectively to integrin αvβ6 PMID 31897589
- Clinical application
- PET imaging of αvβ6 integrin occupancy in lung, relevant to pulmonary fibrosis and some cancers, in preclinical/translational studies PMID 31897589
- Theranostic pair
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Regulatory status
- FDA
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- EMA (centralised)
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- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Modular-Lab (model not stated) Eckert & Ziegler | custom manifold | HPLC | — | >97% | resin bound A20FMDV2 peptide / 4-[18F]fluorobenzoic acid ([18F]FBA) | 31897589 2020 Eur J Nucl Med Mol Imaging The automated GMP-compliant radiosynthesis of [18F]FB-A20FMDV2 was performed on a Modular-Lab™ system (Eckert and Ziegler, Germany). |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
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Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 31897589: 'via conjugation of the resin bound precursor (peptide A20FMDV2) to the prosthetic group 4-[18F]fluorobenzoic acid ([18F]FBA)'. Stage set/updated at stage 23 from PMID 31897589: 'Preclinical evaluation of [18F]FB-A20FMDV2 as a selective marker for measuring αVβ6 integrin occupancy using positron emission tomography in rodent lung.'.