Tracers / [18F]FB-2BD42

[18F]FB-2BD42

Also written as [18F]FB-2BD42; [F-18]FB-2BD42
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
—
Syntheses indexed
1
Glioma and brain tumoursGynaecological cancerLung cancer

What it is

Compound class
Radiofluorinated single domain antibody (sdAb) labelled via [18F]SFB prosthetic group
Target / mechanism
Targets folate receptor-alpha (FR-α), which has elevated expression in epithelial cancers such as ovarian, brain and lung cancers PMID 39048805
Clinical application
PET imaging of folate receptor-alpha (FR-α) overexpression in cancer PMID 39048805
Theranostic pair
—

Regulatory status

FDA
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EMA (centralised)
—
Other approvals
—
Brand names
—

Clinical use

Typical injected activity
—
Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
Manual synthesiscustom manifoldSPE9% (n=1)
yes
>95%[18F]SFB39048805
2024 EJNMMI Radiopharm Chem
the conjugation step was optimised and performed manually — were 9% (n = 1) and 5 ± 2% (n = 3) for [18F]FB-2BD42 and [18F]FB-4AH29, respectively.

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
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USP monograph
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AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18.