Tracer library / [18F]FB-2BD42
[18F]FB-2BD42
Also written as [18F]FB-2BD42; [F-18]FB-2BD42
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 1
What it is
- Compound class
- Radiofluorinated single domain antibody (sdAb) labelled via [18F]SFB prosthetic group
- Target / mechanism
- Targets folate receptor-alpha (FR-α), which has elevated expression in epithelial cancers such as ovarian, brain and lung cancers PMID 39048805
- Clinical application
- PET imaging of folate receptor-alpha (FR-α) overexpression in cancer PMID 39048805
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | custom manifold | SPE | 9% n=1 decay-corrected | >95% | [18F]SFB | 39048805 2024 EJNMMI Radiopharm Chem the conjugation step was optimised and performed manually - were 9% (n = 1) and 5 ± 2% (n = 3) for [18F]FB-2BD42 and [18F]FB-4AH29, respectively. |
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FB-2BD42.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with F-18.