Tracer library / [18F]fallypride
[18F]fallypride
Also written as [18F]Fallypride; [F-18]Fallypride; Fallypride
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 7
What it is
- Compound class
- Radiolabelled substituted benzamide (dopamine D2/D3 receptor antagonist)
- Target / mechanism
- Dopamine D2/D3 receptor ligand PMID 40319441
- Clinical application
- PET imaging of dopamine D2 receptor levels in brain regions in schizophrenia and neuropsychiatric disorders PMID 19251247
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| AllinOne (AiO) Trasis | vendor cassette | HPLC+SPE | 8 ± 2 decay-corrected | >97% | tosylate precursor ABX | 29564391 2017 EJNMMI Radiopharm Chem AllinOne synthesis module - [18F]Fallypride368 ± 22380–320045One vessel, one step, HPLC, SPE |
| AllinOne (AiO) Trasis | vendor cassette | SPE | 59 ± 4% not corrected | 98.4 ± 0.29% | tosyl-fallypride ABX | 40319441 2025 EJNMMI Radiopharm Chem AllinOne synthesis module from Trasis with customized single use cassette operated by the software Trasis Supervision® - yield = 59 ± 4%, not decay corrected |
| AllinOne (AiO) Trasis | vendor cassette | SPE | 31 ± 3% not corrected | 98.9 ± 0.34% | tosyl-fallypride ABX | 40319441 2025 EJNMMI Radiopharm Chem AllinOne synthesis module from Trasis with customized single use cassette operated by the software Trasis Supervision® - yield = 31 ± 3%, not decay corrected |
| Synthra RNplus Synthra | fixed tubing | SPE | 59 ± 4% not corrected | 98.4 ± 0.29% | tosyl-fallypride ABX | 40319441 2025 EJNMMI Radiopharm Chem the Synthra RNplus research module with fixed tubing (RNplus, Synthra, Germany) - yield = 59 ± 4%, not decay corrected |
| Synthra RNplus Synthra | fixed tubing | SPE | 31 ± 3% not corrected | 98.9 ± 0.34% | tosyl-fallypride ABX | 40319441 2025 EJNMMI Radiopharm Chem the Synthra RNplus research module with fixed tubing (RNplus, Synthra, Germany) - yield = 31 ± 3%, not decay corrected |
| ELIXYS FLEX/CHEM Sofie | — | HPLC | — | — | — | 28443841 2017 Lab Chip synthesized using the ELIXYS radiosynthesizer (Sofie Biosciences, Culver City, CA, USA) |
| iMiDEV PMB-Alcen | vendor cassette | HPLC | 11% | >99% | TsO-fallypride ABX | 39692929 2024 EJNMMI Radiopharm Chem the iMiDEV™ radiosynthesiser - RCYa–17 ± 6%10 ± 1%11% |
Clinical literature
Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.
- Dopamine D2 receptor levels in striatum, thalamus, substantia nigra, limbic regions, and cortex in schizophrenic subjects.2009 · Biol Psychiatry · Clinical study
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- ABX
- Typical final purification
- —
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]fallypride.
Get in touchNotes
Added from reverse module search (stage 6); 15 article(s) with F-18. | Stage 28: added indication(s) neu-huntington, psy-schizophrenia from consolidated missing-rubric review.