Tracer library / [18F]F-A-85380

Structure of F-A-85380 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 10241442

[18F]F-A-85380

Also written as [18F]F-A-85380; [F-18]F-A-85380

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 1

Alzheimer's disease Epilepsy Neuroinflammation CNS receptor and transporter imaging Substance use disorders / addiction

What it is

Compound class: radiolabelled nicotinic acetylcholine receptor ligand (fluoropyridine derivative)
Target / mechanism: α4β2 nicotinic acetylcholine receptors (nAChRs) PMID 31168797
Clinical application: Patients with Alzheimer's disease and mild cognitive impairment PMID 18228017
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX FN GE HealthCare	—	—	—	>99%	t-butyloxycarbonyl (BOC)-protected…t-butyloxycarbonyl (BOC)-protected intermediate	17448665 2007 Appl Radiat Isot a commercially available TRACERlab FXF-N synthesis module

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18. | Stage 28: added indication(s) psy-addiction from consolidated missing-rubric review.