Tracers / [18F]F-A-85380
[18F]F-A-85380
Also written as [18F]F-A-85380; [F-18]F-A-85380
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 1
What it is
- Compound class
- radiolabelled nicotinic acetylcholine receptor ligand (fluoropyridine derivative)
- Target / mechanism
- α4β2 nicotinic acetylcholine receptors (nAChRs) PMID 31168797
- Clinical application
- Patients with Alzheimer's disease and mild cognitive impairment PMID 18228017
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | — | — | more than 99% | t-butyloxycarbonyl (BOC)-protected intermediate | 17448665 2007 Appl Radiat Isot a commercially available TRACERlab FXF-N synthesis module |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]F-A-85380.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with F-18. | Stage 28: added indication(s) psy-addiction from consolidated missing-rubric review.