Tracer library / [18F]ApaScan

[18F]ApaScan

Also written as [18F]ApaScan

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Dosimetry and biodistribution studies Adrenal disease (primary aldosteronism, adrenal adenoma)

What it is

Compound class: 6-chloro-5-fluoro-1-(2-[18F]fluoroethyl)-2-(pyridin-3-yl)-1H-benzo[d]imidazole, a fluorine-18 labeled benzimidazole PET tracer
Target / mechanism: CYP11B2 (aldosterone synthase) PMID 41830677
Clinical application: Aldosterone-producing adenomas in patients with primary aldosteronism PMID 41830677
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
FASTlab GE HealthCare	—	HPLC	29.2 ± 0.5% not corrected	>99%	—	41830677 2026 Nucl Med Biol The automated radiosynthesis process was optimized on a cassette-based FASTlab module integrated with preparative HPLC to afford the final formulation (ca. 5% ethanol). - The automated radiosynthesis achieved a non-decay-corrected yield of 29.2 ± 0.5%

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18. | Stage 28: added indication(s) end-adrenal from consolidated missing-rubric review. | Stage 30 (2026-09-18): Stage was 'preclinical (preparing for first-in-human studies)'; normalised to 'Preclinical', original wording kept here.