Tracer library / [18F]AlF-P16-093

[18F]AlF-P16-093

Also written as [18F]AlF-P16-093; [F-18]AlF-P16-093

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 2

Prostate cancer

What it is

Compound class: PSMA-targeted small molecule radiotracer (AlF-labeled PSMA ligand)
Target / mechanism: Prostate specific membrane antigen (PSMA) PMID 38393404
Clinical application: PSMA-PET imaging for prostate cancer staging PMID 38393404
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
PiBOX in-house	custom manifold	SPE	52 ± 4% not corrected	98.6 ± 0.6%	P16-093 In-house / non-commercial (various)	38393404 2024 EJNMMI Radiopharm Chem The automated radiosynthesis system (PiBOX) is a cassette-based, 1-pot device with solid phase extraction (SPE) workup capability - The optimized none-decay-corrected yield was 52 ± 4% (N = 3; 17.5 ± 2.2 GBq)
PiBOX in-house	custom manifold	SPE	49 ± 5% not corrected	97	P16-093 In-house / non-commercial (various)	38393404 2024 EJNMMI Radiopharm Chem The automated radiosynthesis system (PiBOX) is a cassette-based, 1-pot device with solid phase extraction (SPE) workup capability - PiBOX P16-093 80 120 16.7 ± 1.3 49 ± 5% 140 ± 11 SPE (HLB × 1) 150 mg 30

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

First-in-human study of PSMA-targeting agent, [18F]AlF-P16-093: dosimetry and initial evaluation in prostate cancer patients.
2024 · Eur J Nucl Med Mol Imaging · Prospective

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: In-house / non-commercial (various)
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 3 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 38393404: 'P16-093'.