Tracers / [18F]AlF-NOTA-ubiquicidin 29-41

[18F]AlF-NOTA-ubiquicidin 29-41

Also written as [18F]AlF-NOTA-ubiquicidin 29-41

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 1

Infection imaging

What it is

Compound class: NOTA-conjugated antimicrobial peptide (UBI29-41)
Target / mechanism: Binds bacterial cell membranes PMID 40720000
Clinical application: PET/CT imaging of bacterial infections PMID 40720000
Theranostic pair: —

Regulatory status

FDA: —
EMA (centralised): —
Other approvals: —
Brand names: —

Clinical use

Typical injected activity: —
Uptake time: —

Reported in the literature. Not a dosing recommendation.

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Raytest SynChrom Elysia-Raytest	custom manifold	HPLC	24.2 ± 0.6% yes	96.6 ± 0.3%	NOTA-UBI29-41 ABX	40720000 2025 EJNMMI Radiopharm Chem using a modified Elysia Raytest R&D Synchrom module (Straubenhardt, Germany) — with a radiochemical yield of 24.2 ± 0.6% and an apparent molar activity of 45 ± 4 GBq/µmol at end of synthesis (EOS) (n = 3)

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph: —
USP monograph: —

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 40720000: 'NOTA-UBI29-41 (1978.25 g/mol, net peptide) and UBI29-41 (1693.0 g/mol, net peptide) were purchased from ABX'.