Tracers / [18F]AH113804
[18F]AH113804
Also written as [18F]AH113804; [F-18]AH113804; AH113804; GE-212
- Radionuclide
- F-18 t½ 109.7 min
- Modality
- PET
- Production route
- Cyclotron liquid target
- Stage
- Research
- Syntheses indexed
- 0
What it is
- Compound class
- —
- Target / mechanism
- c-Met (hepatocyte growth factor receptor); peptide-based agent with high affinity for human c-Met PMID 26635342 / DOI 10.2967/jnumed.115.164384
- Clinical application
- PET imaging of c-Met expression (studied for early detection of locoregional breast-cancer recurrence); safety, biodistribution and dosimetry assessed in healthy volunteers PMID 26635342 / DOI 10.2967/jnumed.115.164384; PMID 27896673 / DOI 10.1186/s13550-016-0239-y
- Theranostic pair
- —
Regulatory status
- FDA
- No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=AH113804
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- PET acquired ~60 min after injection (healthy-volunteer biodistribution followed up to ~5 h p.i.) PMID 26635342 / DOI 10.2967/jnumed.115.164384; PMID 27896673 / DOI 10.1186/s13550-016-0239-y
Reported in the literature. Not a dosing recommendation.
Published syntheses
No synthesis has been parsed for this agent yet.
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
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Get in touchNotes
Target and application not filled - to be taken from the publication. Stage 26: this agent has NO own synthesis/characterisation data in the current corpus -- its only linked run(s) were unlinked (empty-quote recheck: appeared only as a control/comparator or in the wrong article).