Tracer library / [18F]AF78

[18F]AF78

Also written as [18F]AF78; [F-18]AF78

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Clinical research
Syntheses indexed: 0

Dosimetry and biodistribution studies Cardiac sympathetic innervation / autonomic dysfunction

What it is

Compound class: Norepinephrine transporter (NET) PET tracer
Target / mechanism: Norepinephrine transporter (NET) PMID 42247617
Clinical application: Cardiac sympathetic nerve imaging via NET PET PMID 42247617
Theranostic pair: —

Published syntheses

No synthesis has been parsed for this agent yet.

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

First-In-Human Evaluation of [18F]Fluproxadine for Norepinephrine Transporter PET: Biodistribution, Dosimetry, and Safety.
2026 · Clin Nucl Med · Prospective

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 6 article(s) with F-18. Stage set/updated at stage 23 from PMID 42247617: 'We therefore conducted the first-in-human evaluation of this new class of [18F] labeled NET PET tracer to assess its safety, biodistribution, radiation dosimetry, and imaging characteristics.'. | Stage 28: added indication(s) car-sympathetic from consolidated missing-rubric review. | Stage 30 (2026-09-18): Stage was 'first-in-human'; normalised to 'Clinical research', original wording kept here.