Tracers / [18F]AF78
[18F]AF78
Also written as [18F]AF78; [F-18]AF78
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- first-in-human
- Syntheses indexed
- 2
What it is
- Compound class
- Norepinephrine transporter (NET) PET tracer
- Target / mechanism
- Norepinephrine transporter (NET) PMID 42247617
- Clinical application
- Cardiac sympathetic nerve imaging via NET PET PMID 42247617
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| CFN-MPS200 Sumitomo | — | HPLC+SPE | 1.4–12.0% no | >96% | precursor | 42247617 2026 Clin Nucl Med Automated synthesis was performed on a CFN-MPS200 module (Sumitomo Heavy Industries, Ltd., Tokyo, Japan). — The non-decay-corrected radiochemical yield was 1.4–12.0% |
| — | — | — | 27% | — | — | 32274584 2020 J Neural Transm (Vienna) |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]AF78.
Get in touchNotes
Added from reverse module search (stage 6); 6 article(s) with F-18. Stage set/updated at stage 23 from PMID 42247617: 'We therefore conducted the first-in-human evaluation of this new class of [18F] labeled NET PET tracer to assess its safety, biodistribution, radiation dosimetry, and imaging characteristics.'. | Stage 28: added indication(s) car-sympathetic from consolidated missing-rubric review.