Tracers / [18F]6-O-desmethyl-diprenorphine

[18F]6-O-desmethyl-diprenorphine

Also written as [18F]6-O-desmethyl-diprenorphine; [F-18]6-O-desmethyl-diprenorphine
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
—
Syntheses indexed
2
CNS receptor and transporter imaging

What it is

Compound class
opioid receptor radioligand (diprenorphine derivative)
Target / mechanism
μ-opioid receptors PMID 37685958
Clinical application
PET imaging of brain opioid receptors PMID 37685958
Theranostic pair
—

Regulatory status

FDA
—
EMA (centralised)
—
Other approvals
—
Brand names
—

Clinical use

Typical injected activity
—
Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
TRACERlab FX FE
GE HealthCare
custom manifoldHPLC44.5 ± 10.6%
yes
>99%6-O-(2-tosyloxyethyl)-6-O-desmethyl-3-O-trityl-diprenorphine (TE-TDDPN)
ABX
37685958
2023 Int J Mol Sci
modified GE Tracerlab FX FE synthesis panel — 44.5 ± 10.6 RCY (decay-corrected)
——————24692062
2014 J Labelled Comp Radiopharm
GE TRACERlab FXFE radiochemistry module

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
—
USP monograph
—
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18.