Tracer library / [18F]6-O-desmethyl-diprenorphine

[18F]6-O-desmethyl-diprenorphine

Also written as [18F]6-O-desmethyl-diprenorphine; [F-18]6-O-desmethyl-diprenorphine

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 2

CNS receptor and transporter imaging

What it is

Compound class: opioid receptor radioligand (diprenorphine derivative)
Target / mechanism: μ-opioid receptors PMID 37685958
Clinical application: PET imaging of brain opioid receptors PMID 37685958
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX FE GE HealthCare	custom manifold	HPLC	44.5 ± 10.6% decay-corrected	>99%	6-O-(2-tosyloxyethyl)-6-O-desmethyl-3-O-trit…6-O-(2-tosyloxyethyl)-6-O-desmethyl-3-O-trityl-diprenorphine (TE-TDDPN) ABX	37685958 2023 Int J Mol Sci modified GE Tracerlab FX FE synthesis panel - 44.5 ± 10.6 RCY (decay-corrected)
TRACERlab FX FE GE HealthCare	—	—	—	—	—	24692062 2014 J Labelled Comp Radiopharm GE TRACERlab FXFE radiochemistry module

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: ABX
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18.