Tracer library / [57Co]Co-NOTA-PEG2-RM26

[57Co]Co-NOTA-PEG2-RM26

Also written as [57Co]Co-NOTA-PEG2-RM26
Radionuclide
Co-57
Modality
—
Production route
—
Stage
Preclinical
Syntheses indexed
2
Prostate cancerReceptor expression phenotyping

What it is

Compound class
GRPR-antagonist peptide (bombesin analogue RM26) conjugated with NOTA chelator via PEG2 linker
Target / mechanism
Gastrin releasing peptide receptor (GRPR) PMID 29097932
Clinical application
Prostate cancer imaging via GRPR expression PMID 29097932
Theranostic pair
—

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
Manual synthesis————NOTA-PEG2-RM2633352838
2020 Molecules
Labeling with 57Co was performed using 1 nmol (aq. 0.1 nmol/µL) of X-RM26 buffered with 100 µL ammonium acetate (0.2 M, pH 5.5).
Manual synthesis——>99%—NOTA-PEG2-RM2629097932
2017 Contrast Media Mol Imaging
Radiolabeling with 57Co was performed using 3.8–10 nmol (aq. 1 nmol/μL) of NOTA-PEG2-RM26 buffered with 80 μL ammonium acetate (0.2 M, pH 5.5). The mixture was incubated with 57Co cobalt chloride (10–50 MBq) for 30 min at 60°C. — Labeling was successful, with yields exceeding 99% for 57Co and 98% for 55Co.

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Notes

Added at stage 39 (2026-09-27) from a reverse search of the PubMed corpus's own unattached articles (articles that named a real compound not yet in this reference): 2 article(s) found under this name, not yet individually researched. Target/mechanism, clinical application, indications, approval, modality, stage and production route are intentionally left empty. PMIDs: 29097932, 33352838. Compound class inferred from precursor name (not stated outright) -- PMID 29097932: 'NOTA-PEG2-RM26 was successfully radiolabeled with 57Co and 55Co with high yields and demonstrated high stability.'. Stage set/updated at stage 39 from PMID 29097932: 'The favorable biodistribution of cobalt-labeled NOTA-PEG2-RM26 translated into high contrast preclinical PET/CT (using 55Co) and SPECT/CT (using 57Co) images of PC-3 xenografts.'.