Tracers / [11C](+)-PHNO
[11C](+)-PHNO
Also written as [11C](+)-PHNO
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 6
What it is
- Compound class
- dopamine D2/D3 receptor agonist radioligand (aminotetralin-derivative)
- Target / mechanism
- Dopamine D2/D3 receptor agonist, D3-preferential PMID 32818617
- Clinical application
- PET imaging of dopamine D2/D3 receptor availability and dopamine release in the human brain (research use in healthy subjects and psychosis patients) PMID 32066718
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX C Pro GE HealthCare | custom manifold | HPLC+SPE | 8.25±4.2% | — | (+)-HNO hydrochloride ABX | 23974301 2013 Appl Radiat Isot Preparations were performed on the TRACERlab™ FX C Pro synthesis platform (GE Healthcare, Uppsala, Sweden) including semi-preparative HPLC, SPE purification and product formulation. — Overall synthesis outcome was 8.25±4.2% (1.83±0.55 GBq, range 1.16–3.0 GBq, n=11; end of synthesis, EOS) within 37±2 min. |
| — | — | — | — | — | — | 26058690 2015 J Cereb Blood Flow Metab |
| — | — | — | — | — | — | 32818617 2020 Neuroimage |
| — | — | — | — | — | — | 34544031 2021 Neuroimage Clin |
| Manual synthesis | — | — | 13 ± 2% | — | alkyl bromide precursor | 33238289 2021 Nature After 12 hours of blue light irradiation in the integrated photoreactor — [11C]PHNO was conveniently prepared in sufficient yields for in vivo imaging studies (13 ± 2% yield) |
| — | — | — | — | — | — | 32066718 2020 Transl Psychiatry |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C](+)-PHNO.
Get in touchNotes
Added from reverse module search (stage 6); 4 article(s) with C-11. | Stage 28: added indication(s) psy-schizophrenia from consolidated missing-rubric review.