Tracers / [11C]methionine
[11C]methionine
Also written as [11C]MET; [11C]Methionine; [C-11]MET; [C-11]Methionine; C-11 MET; C-11-MET; MET
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 13
What it is
- Compound class
- Radiolabelled amino acid (L-methionine, 11C in the methyl group)
- Target / mechanism
- L-type amino acid transporter 1 (LAT1), upregulated in gliomas and brain metastases PMID 20091333
- Clinical application
- Brain tumour (glioma) PET imaging: initial diagnosis, grading, recurrence vs. radiation-injury differentiation PMID 20091333
- Theranostic pair
- —
Regulatory status
- FDA
- No FDA (Drugs@FDA/openFDA): no 11C-methionine product found (search 'methionine' returns only parenteral-nutrition amino-acid mixtures)
- EMA (centralised)
- No EMA medicines register export (2026-09-09): no 'methionine' PET entry
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | HPLC | — | >99.5% | — | 31673030 2019 Sci Rep |
| CFN-MPS100 Sumitomo | — | none | — | — | — | 27744544 2017 Ann Nucl Med 11C-CH3I and 11C-methylated compounds were prepared using a multipurpose synthesizer CFN-MPS100 (Sumitomo Heavy Industries) |
| C-MET100 (methionine synthesizer) Sumitomo | custom manifold | SPE | — | >95% | L-homocysteine thiolactone hydrochloride | 34061417 2021 Cancer Sci an automated synthesis apparatus dedicated to 11C‐MET synthesis (C‐MET100; Sumitomo Heavy Industries) |
| iMiDEV PMB-Alcen | vendor cassette | SPE | 84 ± 4% yes | >96.0% | L-homocysteine thiolactone Sigma-Aldrich | 38399466 2024 Pharmaceuticals (Basel) a microfluidic cassette and an iMiDEVTM module by employing a dose-on-demand approach — The radiochemical yield (RCY) was 84 ± 4%, and the synthesis time was 18 ± 1 min (n = 3). |
| — GE HealthCare | custom manifold | HPLC | — | — | [11C]NaCN | 29430080 2017 Synlett a GE TRACERLab FXM synthesis module was adapted to enable automated Strecker reactions |
| — | — | — | — | — | — | 26877786 2016 Theranostics |
| — | — | SPE | 20 ± 5% | 95.4 ± 3.6% | two different precursors | 33153893 2021 Appl Radiat Isot We have used FX2C and FX2N Tracerlab modules for the synthesis of the [11C]methionine, [18F]choline and [18F]fluorodopa via nucleophilic pathway in FX2C/N module. — with yield of 20 ± 5% |
| — | — | — | — | — | — | 27694174 2016 J Nucl Med |
| — | — | — | — | — | — | 30196247 2018 Appl Radiat Isot a fully automated GE TRACERlab FX C Pro synthesizer |
| — | — | SPE | 75 +/- 3% | — | L-homocysteine thiolactone hydrochloride | 21721254 2011 Bioorg Khim [11C] MET synthesis was performed on a fully automated module designed by the Institute of Human Brain (IHB RAS). — sufficiently high radiochemical yield (75 +/- 3%, n = 100, based on [11C]CH3I) |
| — | — | — | — | — | — | 20685129 2010 Appl Radiat Isot modules from Eckert & Ziegler Modular Lab System |
| — | — | — | — | — | — | 17158055 2007 Appl Radiat Isot A modification of commercial [11C]methylation module which can be implemented for both on-column [11C]methylation and [11C]carboxylation in the same automated system is described. |
| — | — | — | — | — | — | 8698067 1996 Eur J Nucl Med |
Need this precursor?We can point you to suppliers for [11C]methionine, or handle the enquiry for you.
Get in touchQuality control Pharmacopoeial monograph
- Ph. Eur. monograph
- 1617
- USP monograph
- not verified — the USP-NF monograph index is subscription-only and no public confirmation was found
How this set was arrived at. Base set per Ph. Eur. 0125 + monograph 1617. Short half-life -> compressed release; endotoxin/sterility retrospective. Monograph under revision (pH method).
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C]methionine.
Get in touchNotes
Added from reverse module search (stage 6); 18 article(s) with C-11.