Tracer library / [11C]Me-NB1

Structure of Me-NB1 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 46845430

[11C]Me-NB1

Also written as [11C]Me-NB1; [C-11]Me-NB1

Radionuclide: C-11 t½ 20.36 min
Modality: PET
Production route: —
Stage: Clinical research
Syntheses indexed: 0

Dosimetry and biodistribution studies

What it is

Compound class: GluN2B-specific NMDA receptor PET radioligand (des-methyl precursor (R)-NB1)
Target / mechanism: GluN2B subunit of the NMDA receptor PMID 36018389
Clinical application: Biodistribution and dosimetry study in healthy subjects; potential for longitudinal studies in drug development and treatment monitoring of neuropsychiatric and neurodegenerative diseases PMID 36018389
Theranostic pair: —

Published syntheses

No synthesis has been parsed for this agent yet.

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with C-11. Compound class inferred from precursor name (not stated outright) -- PMID 36018389: 'des-methyl GMP-grade precursor (R)-NB1'. Stage set/updated at stage 23 from PMID 36018389: 'the novel GluN2B-specific PET radioligand (R)-[11C]Me-NB1 was investigated in rodents and for the first time successfully translated to humans'. | Stage 30 (2026-09-18): Stage was 'first-in-human'; normalised to 'Clinical research', original wording kept here.