Tracers / [11C]Me-NB1
[11C]Me-NB1
Also written as [11C]Me-NB1; [C-11]Me-NB1
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- first-in-human
- Syntheses indexed
- 1
What it is
- Compound class
- GluN2B-specific NMDA receptor PET radioligand (des-methyl precursor (R)-NB1)
- Target / mechanism
- GluN2B subunit of the NMDA receptor PMID 36018389
- Clinical application
- Biodistribution and dosimetry study in healthy subjects; potential for longitudinal studies in drug development and treatment monitoring of neuropsychiatric and neurodegenerative diseases PMID 36018389
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX2 C GE HealthCare | — | HPLC+SPE | — | — | (R)-NB1 | 36018389 2022 EJNMMI Res fully-automated GE Tracerlab™ FX2 C synthesis module |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C]Me-NB1.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with C-11. Compound class inferred from precursor name (not stated outright) -- PMID 36018389: 'des-methyl GMP-grade precursor (R)-NB1'. Stage set/updated at stage 23 from PMID 36018389: 'the novel GluN2B-specific PET radioligand (R)-[11C]Me-NB1 was investigated in rodents and for the first time successfully translated to humans'.