Tracers / [11C]ER176

What it is

Compound class
Third-generation TSPO PET radioligand
Target / mechanism
18 kDa translocator protein (TSPO) PMID 38641899
Clinical application
Neuroinflammation imaging across the Alzheimer's disease spectrum PMID 41574776
Theranostic pair

Regulatory status

FDA
EMA (centralised)
Other approvals
Brand names

Clinical use

Typical injected activity
Uptake time

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
HPLC38641899
2024 J Labelled Comp Radiopharm

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
USP monograph
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with C-11. | Stage 28: added indication(s) neu-tbi, psy-mood from consolidated missing-rubric review.