Tracers / [11C]DASB
[11C]DASB
Also written as [11C]DASB; [C-11]DASB; DASB
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 4
What it is
- Compound class
- O-desmethyl DASB derived carbon-11 methylated arylthiophenylamine SERT ligand
- Target / mechanism
- Serotonin transporter (SERT) PMID 36071112
- Clinical application
- —
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX C Pro GE HealthCare | custom manifold | HPLC+SPE | 3.0% no | >95% | O-desmethyl DASB ABX | 23123138 2013 Nucl Med Biol Ethanolic loop chemistry is fully automated using a GE TRACERLab FXC-Pro synthesis module — 3.0% RCY; >95% RCP; SA = 15152 Ci/mmol; n = 9 |
| TRACERlab FX C Pro GE HealthCare | custom manifold | HPLC+SPE | 3.0% no | >95% | O-desmethyl DASB ABX | 23123138 2013 Nucl Med Biol Ethanolic loop chemistry is fully automated using a GE TRACERLab FXC-Pro synthesis module — 3.0% RCY; >95% RCP; SA = 10931 Ci/mmol; n = 3 |
| — | — | — | — | — | — | 36071112 2022 Mol Psychiatry |
| — | — | — | 66.3+/-6.9% yes | — | [11C]CH3I | 19359188 2009 Appl Radiat Isot |
Need this precursor?We can point you to suppliers for [11C]DASB, or handle the enquiry for you.
Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C]DASB.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with C-11. Compound class inferred from precursor name (not stated outright) -- PMID 23123138: 'O-desmethyl DASB (1.0 mg) in ethanol (100 µL)'.