Tracer library / [11C]DASB

Structure of DASB (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 10446567

[11C]DASB

Also written as [11C]DASB; [C-11]DASB; DASB

Radionuclide: C-11 t½ 20.36 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 3

CNS receptor and transporter imaging

What it is

Compound class: O-desmethyl DASB derived carbon-11 methylated arylthiophenylamine SERT ligand
Target / mechanism: Serotonin transporter (SERT) PMID 36071112
Clinical application: Measurement of serotonin transporter occupancy in brain after citalopram administration in patients with major depression and healthy volunteers PMID 36071112
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX C Pro GE HealthCare	custom manifold	HPLC+SPE	3.0% not corrected	>95%	O-desmethyl DASB ABX	23123138 2013 Nucl Med Biol Ethanolic loop chemistry is fully automated using a GE TRACERLab FXC-Pro synthesis module - 3.0% RCY; >95% RCP; SA = 15152 Ci/mmol; n = 9
TRACERlab FX C Pro GE HealthCare	custom manifold	HPLC+SPE	3.0% not corrected	>95%	O-desmethyl DASB ABX	23123138 2013 Nucl Med Biol Ethanolic loop chemistry is fully automated using a GE TRACERLab FXC-Pro synthesis module - 3.0% RCY; >95% RCP; SA = 10931 Ci/mmol; n = 3
—	—	—	66.3+/-6.9% decay-corrected	—	[11C]CH3I	19359188 2009 Appl Radiat Isot

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

ABCB1 variants and sex affect serotonin transporter occupancy in the brain.
2022 · Mol Psychiatry · Clinical study

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: ABX
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with C-11. Compound class inferred from precursor name (not stated outright) -- PMID 23123138: 'O-desmethyl DASB (1.0 mg) in ethanol (100 µL)'.