Tracer library / [11C]CP31398
[11C]CP31398
Also written as [11C]CP31398; [C-11]CP31398
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- Preclinical
- Syntheses indexed
- 1
What it is
- Compound class
- Isotopically labeled small molecule (styrylquinazoline, phenol precursor radiomethylation)
- Target / mechanism
- Mutant protein p53 (originally designed to target; findings show it does not bind p53 directly but an unidentified target) PMID 41696278
- Clinical application
- Imaging of mutant p53 expressing tumors for cancer patient stratification and drug development PMID 41696278
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX C Pro GE HealthCare | — | HPLC | 40 ± 13 decay-corrected | >99% | phenol precursor 2 | 41696278 2026 ACS Omega the whole radiochemical process was automated using the TRACERlab FX C Pro module and the optimized conditions - afforded ready-to-inject [11C]CP31398 (0.6–1.6 GBq) in 40 ± 13% (n = 6) RCY within 40 min (nondecay corrected activity yield of 10 ± 3%) |
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C]CP31398.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with C-11. Stage set/updated at stage 23 from PMID 41696278: 'Binding experiments performed with [18F]FG-CP31398 on HEK-293T cells transfected with a green fluorescent protein-p53 wild-type plasmid'. Compound class inferred from precursor name (not stated outright) -- PMID 41696278: 'the phenol precursor 2 in 75% yield'.