Tracers / [11C]choline
[11C]choline
Also written as [11C]Choline; [C-11]Choline; Choline
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- Approved
- Syntheses indexed
- 8
What it is
- Compound class
- Radiolabelled choline analogue (11C in the methyl group)
- Target / mechanism
- Choline kinase / choline transport, reflecting increased membrane-phospholipid synthesis in tumour cells PMID 23579863
- Clinical application
- Prostate-cancer restaging (biochemical recurrence) PMID 23579864
- Theranostic pair
- —
Regulatory status
- FDA
- 2012, Choline C-11, Mayo Clinic PET Radiochemistry Facility (MCPRF) FDA (Drugs@FDA/openFDA): NDA203155, approved 2012-09-12
- EMA (centralised)
- No EMA medicines register export (2026-09-09): no 'choline' PET entry
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| iMiDEV PMB-Alcen | vendor cassette | SPE | 66 ± 2% yes | >99.0% | dimethylaminoethanol (DMAE) Sigma-Aldrich | 38399466 2024 Pharmaceuticals (Basel) a microfluidic cassette and an iMiDEVTM module by employing a dose-on-demand approach — the optimized precursor volume for [11C]choline was 25 µL, and the RCY was 66 ± 2%. |
| TRACERlab FX FE GE HealthCare | custom manifold | SPE | 52 yes | >99% | N,N'-dimethylaminoethanol (DMAE) Sigma-Aldrich | 35347490 2022 EJNMMI Radiopharm Chem The labelling reactions were controlled with a TRACERlab Fx FE module. — 898 MBq (decay corrected 52%) of [11C]choline were isolated after 22 min |
| — | — | — | — | — | — | 26877786 2016 Theranostics |
| — | — | — | — | — | — | 27694174 2016 J Nucl Med |
| — | — | — | — | 99.79 ± 0.14 % | — | 22762159 2012 Med Chem using TRACERlab FXc module that utilized gas phase iodination |
| — | — | SPE | >60% | 99.9% | — | 21115355 2011 Appl Radiat Isot Modifications of a GE TracerLab FX(C-Pro), which can be implemented for solid-phase [(11)C]methylation are described. — Typical radiochemical yields (RCY) are >60% |
| — | — | — | — | — | — | 20685129 2010 Appl Radiat Isot modules from Eckert & Ziegler Modular Lab System |
| — | — | — | — | — | — | 17158055 2007 Appl Radiat Isot A modification of commercial [11C]methylation module which can be implemented for both on-column [11C]methylation and [11C]carboxylation in the same automated system is described. |
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Get in touchQuality control Pharmacopoeial monograph
- Ph. Eur. monograph
- 2462
- USP monograph
- not verified — USP-NF monograph index is subscription-only; a Choline C 11 Injection monograph is expected (FDA-approved 2012) but not publicly confirmed here
How this set was arrived at. Cross-checked against Ph. Eur. general monograph 0125 (base set), EANM validation guideline (PMC7016057) and cGRPP guidance (PMC7881071). Draft X-marks consistent with the base set; tracer-specific analytical tests follow the specific monograph where one exists.
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C]choline.
Get in touchNotes
Added from reverse module search (stage 6); 6 article(s) with C-11. Stage set to 'Approved' at stage 23 -- Approval FDA field on this row (2012, Choline C-11, Mayo Clinic PET Radiochemistry Facility (MCPRF)).