Tracer library / [11C]acetate
[11C]acetate
Also written as [11C]Acetate; [C-11]Acetate; Acetate
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 9
What it is
- Compound class
- short-chain carboxylic acid (radiolabelled acetate) / fatty acid metabolic PET tracer
- Target / mechanism
- Oxidative and fatty acid metabolism tracer; assesses oxidative metabolism and ketone body utilization pathway (acetate metabolism) PMID 41452397
- Clinical application
- Cardiac PET imaging for myocardial oxidative metabolism/external efficiency assessment PMID 29946824
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX2 C GE HealthCare | custom manifold | SPE | 35.8 ± 9.9% decay-corrected | 96.9 ± 2.8% | methylmagnesium chloride (MeMgCl) Erbitux, Merck | 41452397 2025 EJNMMI Radiopharm Chem a GE TRACERlab FX2 C module - The decay-corrected RCY was 35.8 ± 9.9% after an average synthesis time of 10 min |
| TRACERlab FX FE GE HealthCare | custom manifold | SPE | 51 ± 5 decay-corrected | — | MeMgCl (methyl magnesium chloride) in THF Sigma-Aldrich | 35347490 2022 EJNMMI Radiopharm Chem a representative [11C]acetate synthesis using a TRACERlab FX FE module - pure [11C]acetate (n = 10) was isolated with a decay corrected yield of 51 ± 5% |
| AllinOne (AiO) Trasis | vendor cassette | SPE | — | — | methylmagnesium chloride/bromide (3.0 M,…methylmagnesium chloride/bromide (3.0 M, THF) Sigma-Aldrich | 35044650 2022 Methods Mol Biol TRASIS AIO |
| TRACERlab FX C Pro GE HealthCare | — | — | 56 ± 7% | — | [11C]CO2 | 35964418 2022 Appl Radiat Isot The TRACERLab FX C Pro Synthesizer can be used this sensitive carboxylation reaction. - yield 56 ± 7%, n = 10 |
| TRACERlab FX C Pro GE HealthCare | — | SPE | — | — | — | 23941748 2013 Appl Radiat Isot Easy upgrade of the TRACERLab FX C Pro for [¹¹C]carboxylation reactions |
| — | — | SPE | 41.0 ± 4.6% not corrected | >95% | (11)C-CO2 | 23974302 2013 Appl Radiat Isot using a commercially available (11)C-tracer synthesizer - A high and reproducible decay-uncorrected radiochemical yield of (41.0 ± 4.6)% (n=10) was obtained from (11)C-CO2 |
| TRACERlab FX C Pro GE HealthCare | — | — | 18% not corrected | >98% | — | 21256039 2011 Appl Radiat Isot automated on the GE Tracerlab FX(C-Pro) by utilizing Grignard reactions - average non-corrected yields of 18% (n = 3) |
| TRACERlab FX (model not stated) GE HealthCare | — | — | — | — | methylmagnesium chloride | 17158055 2007 Appl Radiat Isot A modification of commercial [11C]methylation module which can be implemented for both on-column [11C]methylation and [11C]carboxylation in the same automated system is described. |
| — | — | SPE | — | — | methylmagnesium Grignard | 12088733 2002 Nucl Med Biol We have designed a fully-automated robotic system for the compounding of this 20-minute half-lived tracer in the clinical setting. |
Clinical literature
Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.
- Early prediction of synergistic cardiotoxicity induced by PD-1 inhibitors and doxorubicin using cardiac 18F-FDG PET/MRI.2026 · Chin J Cancer Res · Prospective
- Automatic calculation of myocardial external efficiency using a single 11C-acetate PET scan.2018 · J Nucl Cardiol · Clinical study
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- Erbitux, Sigma-Aldrich
- Typical final purification
- —
Need this precursor?We can point you to suppliers for [11C]acetate, or handle the enquiry for you.
Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C]acetate.
Get in touchNotes
Added from reverse module search (stage 6); 6 article(s) with C-11. | Stage 29 (2026-09-14): cleared Theranostic pair -> y90-acetate (that row deleted as a data-quality fragment; see Removed sheet).