Tracers / [11C]acetate
[11C]acetate
Also written as [11C]Acetate; [C-11]Acetate; Acetate
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 13
What it is
- Compound class
- short-chain carboxylic acid (radiolabelled acetate) / fatty acid metabolic PET tracer
- Target / mechanism
- Oxidative and fatty acid metabolism tracer; assesses oxidative metabolism and ketone body utilization pathway (acetate metabolism) PMID 41452397
- Clinical application
- Cardiac PET imaging for myocardial oxidative metabolism/external efficiency assessment PMID 29946824
- Theranostic pair
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Regulatory status
- FDA
- —
- EMA (centralised)
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- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX2 C GE HealthCare | custom manifold | SPE | 35.8 ± 9.9% yes | 96.9 ± 2.8% | methylmagnesium chloride (MeMgCl) Erbitux, Merck | 41452397 2025 EJNMMI Radiopharm Chem a GE TRACERlab FX2 C module — The decay-corrected RCY was 35.8 ± 9.9% after an average synthesis time of 10 min |
| — | custom manifold | — | — | — | — | 18925023 1995 J Automat Chem A fully automated apparatus for the synthesis and formulation of short-lived 11C (t1/2 = 20 min)-labeled carboxylic acids for positron emission tomograpy (PET) has been developed. |
| TRACERlab FX FE GE HealthCare | custom manifold | SPE | 51 ± 5 yes | — | MeMgCl (methyl magnesium chloride) in THF Sigma-Aldrich | 35347490 2022 EJNMMI Radiopharm Chem a representative [11C]acetate synthesis using a TRACERlab FX FE module — pure [11C]acetate (n = 10) was isolated with a decay corrected yield of 51 ± 5% |
| — | — | — | — | — | — | 29946824 2018 J Nucl Cardiol |
| AllinOne (AiO) Trasis | vendor cassette | SPE | — | — | methylmagnesium chloride/bromide (3.0 M, THF) Sigma-Aldrich | 35044650 2022 Methods Mol Biol TRASIS AIO |
| — | — | — | — | — | — | 26877786 2016 Theranostics |
| — | — | — | — | — | — | 17332620 2007 J Nucl Med |
| — | — | — | 56 ± 7% | — | [11C]CO2 | 35964418 2022 Appl Radiat Isot The TRACERLab FX C Pro Synthesizer can be used this sensitive carboxylation reaction. — yield 56 ± 7%, n = 10 |
| — | — | SPE | — | — | — | 23941748 2013 Appl Radiat Isot Easy upgrade of the TRACERLab FX C Pro for [¹¹C]carboxylation reactions |
| — | — | SPE | 41.0 ± 4.6% no | over 95% | (11)C-CO2 | 23974302 2013 Appl Radiat Isot using a commercially available (11)C-tracer synthesizer — A high and reproducible decay-uncorrected radiochemical yield of (41.0 ± 4.6)% (n=10) was obtained from (11)C-CO2 |
| — | — | — | 18% no | >98% | — | 21256039 2011 Appl Radiat Isot automated on the GE Tracerlab FX(C-Pro) by utilizing Grignard reactions — average non-corrected yields of 18% (n = 3) |
| — | — | — | — | — | methylmagnesium chloride | 17158055 2007 Appl Radiat Isot A modification of commercial [11C]methylation module which can be implemented for both on-column [11C]methylation and [11C]carboxylation in the same automated system is described. |
| — | — | SPE | — | — | methylmagnesium Grignard | 12088733 2002 Nucl Med Biol We have designed a fully-automated robotic system for the compounding of this 20-minute half-lived tracer in the clinical setting. |
Need this precursor?We can point you to suppliers for [11C]acetate, or handle the enquiry for you.
Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C]acetate.
Get in touchNotes
Added from reverse module search (stage 6); 6 article(s) with C-11. | Stage 29 (2026-09-14): cleared Theranostic pair -> y90-acetate (that row deleted as a data-quality fragment; see Removed sheet).