Tracer library / [225Ac]Ac-FAPI-04

Structure of FAPI-04 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 138454803

[225Ac]Ac-FAPI-04

Also written as FAPI-04; [Ac-225]Ac-FAPI-04

Radionuclide: Ac-225 t½ 14284.8 min
Modality: Therapy
Production route: —
Stage: Preclinical
Syntheses indexed: 0

Fibroblast activation / tumour stroma

What it is

Compound class: FAP inhibitor (FAPI)
Target / mechanism: Targets fibroblast activation protein (FAP) expressed on cancer-associated fibroblasts PMID 41599688
Clinical application: Oncology - tumours with prominent cancer-associated fibroblast/stromal content PMID 41599688
Theranostic pair: [68Ga]Ga-FAPI-04

Published syntheses

No synthesis has been parsed for this agent yet.

Need this precursor?We can point you to suppliers for [225Ac]Ac-FAPI-04, or handle the enquiry for you.

Get in touch

Notes

Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 1 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Diagnostic pair signal at discovery: YES - Ga-68. Stage set/updated at stage 23 from PMID 41599688: 'α-emitting radiotracers (e.g., [225Ac]Ac-FAPI-04) demonstrate potent antitumor effects in preclinical models.'.