Tracer library / [89Zr]ZrCl4

Structure of ZrCl4 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 24817

[89Zr]ZrCl4

Also written as [89Zr]ZrCl4

Radionuclide: Zr-89 t½ 4704 min
Modality: PET
Production route: —
Stage: Clinical research
Syntheses indexed: 2

Radiochemistry methodology Radiolabelling starting material

What it is

Compound class: Zirconium-89 radiolabeling starting material (89Zr4+ chloride form)
Target / mechanism: —
Clinical application: —
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	custom manifold	none	80-90%	> 95%	H3DFOSq-bisPSMA	38717578 2024 EJNMMI Radiopharm Chem We first repeated published procedures for the preparation of [89Zr]ZrCl4 using a Quaternary Methyl Ammonium (QMA) strong anion exchange cartridge - the activity was eluted as [89Zr]ZrCl4with 400 µL of 1.0 M HCl in a typical recovery of 80–90%.
miniAllinOne Trasis	vendor cassette	—	94 ± 6%	≥99.8%	89Y target coins Artms, Inc., Vancouver, Canada	39094425 2024 Nucl Med Biol a miniAllinOne (miniAIO) cassette-based synthesizer from TRASIS (Ans, Belgium) was used - The mean radiochemical isolation yield was 94 ± 6%.

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: Artms, Inc.
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMetal impurities

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with Zr-89. Stage set/updated at stage 39 from PMID 34932154: 'The patient received 90.5 MBq 89Zr-PSMA-617 followed by PET/CT imaging.'.