Tracers / [89Zr]ZrCl4
[89Zr]ZrCl4
Also written as [89Zr]ZrCl4
- Radionuclide
- Zr-89 t½ 4704 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 2
What it is
- Compound class
- Zirconium-89 radiolabeling starting material (89Zr4+ chloride form)
- Target / mechanism
- —
- Clinical application
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- Theranostic pair
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Regulatory status
- FDA
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- EMA (centralised)
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- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | custom manifold | none | 80-90% | > 95% | H3DFOSq-bisPSMA | 38717578 2024 EJNMMI Radiopharm Chem We first repeated published procedures for the preparation of [89Zr]ZrCl4 using a Quaternary Methyl Ammonium (QMA) strong anion exchange cartridge — the activity was eluted as [89Zr]ZrCl4with 400 µL of 1.0 M HCl in a typical recovery of 80–90%. |
| miniAllinOne Trasis | vendor cassette | — | 94 ± 6% | ≥99.8% | 89Y target coins Artms, Inc., Vancouver, Canada | 39094425 2024 Nucl Med Biol a miniAllinOne (miniAIO) cassette-based synthesizer from TRASIS (Ans, Belgium) was used — The mean radiochemical isolation yield was 94 ± 6%. |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [89Zr]ZrCl4.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with Zr-89.