Tracer library / [90Y]Y-PSMA-617
[90Y]Y-PSMA-617
Also written as PSMA-617; Pluvicto
- Radionuclide
- Y-90 t½ 3843.6 min
- Modality
- Therapy
- Production route
- —
- Stage
- —
- Syntheses indexed
- 3
What it is
- Compound class
- PSMA-617 DOTA-conjugated small molecule (urea-based PSMA-targeting ligand)
- Target / mechanism
- —
- Clinical application
- —
- Theranostic pair
- [111In]In-PSMA-617
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Modular-Lab EAZY Eckert & Ziegler | vendor cassette | SPE | 76.4 ± 2.2% | >99% TLC, >98% HPLC | PSMA-617 Gamma Servizi s.r.l., Pavia, Italy | 29097938 2017 Contrast Media Mol Imaging The ML Eazy system was also tested to prepare 90Y- and 177Lu-PSMA-617 - average RCYs of 76.4 ± 2.2% (n = 5) ... for yttrium-90 |
| Modular-Lab EAZY Eckert & Ziegler | vendor cassette | SPE | 76.4 ± 2.2 | >99% TLC, >98% HPLC | PSMA-617 Gamma Servizi s.r.l., Pavia, Italy | 29097938 2017 Contrast Media Mol Imaging Modular-Lab Eazy automatic synthesizer, disposable cassettes (C0-YDOTAPEP-CM, C0-LUDOTAPEP-CM, C0-YDOTAPSMA-CM, and C0-LUDOTAPSMA-CM), hardware, and reagent kits were supplied by Eckert & Ziegler Eurotope GmbH (Berlin, Germany). - average RCYs of 76.4 ± 2.2% (n = 5) and 90.1 ± 0.8% (n = 5), for yttrium-90 and lutetium-177, respectively, were achieved |
| Manual synthesis n/a | — | — | — | >95% | PSMA-617 | 30770227 2019 Nucl Med Biol A two-step radiochemical separation procedure based on selective precipitation of 90Y under alkaline conditions from 90Sr/90Y equilibrium mixture was developed. |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- Gamma Servizi s.r.l.
- Typical final purification
- —
Need this precursor?We can point you to suppliers for [90Y]Y-PSMA-617, or handle the enquiry for you.
Get in touchNotes
Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 1 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Diagnostic pair signal at discovery: YES - Ga-68, In-111. Compound class inferred from precursor name (not stated outright) -- PMID 29097938: 'PSMA-617'.