Tracer library / [99mTc]Tc-TcO4

[99mTc]Tc-TcO4

Also written as [99mTc]NaTcO4; [99mTc]TcO4; [Tc-99m]NaTcO4; [Tc-99m]TcO4

Radionuclide: Tc-99m t½ 360.6 min
Modality: SPECT
Production route: —
Stage: —
Syntheses indexed: 1

Parathyroid imaging Thyroid function and NIS expression

What it is

Compound class: Pertechnetate (free 99mTc-labeled anion, [99mTc]TcO4-)
Target / mechanism: Sodium/iodide symporter (NIS)-mediated uptake in thyroid follicular cells PMID 35124101
Clinical application: Thyroid functional and molecular imaging (thyrotoxicosis, thyroid nodules) and parathyroid imaging (subtraction scintigraphy) PMID 35124101
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	none	89.8%	89.8%	4	40135799 2025 J Med Chem Similarly, the RCP of the product was determined by radio-HPLC (methods A and B) and the absence of 99mTc/99Tc-colloid formation was confirmed by radio-TLC. - except for [99mTc]TcO-4 (89.8%)

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

[99mTc]Tc-Sestamibi/[99mTc]NaTcO4 Subtraction SPECT of Parathyroid Glands Using Analysis of Principal Components.
2025 · J Nucl Med Technol · Clinical study

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMetal impurities

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with Tc-99m. Merged stage 17: +1 article(s) from tc99m-natco4 (same species, pertechnetate anion); combined count 3.