Tracer library / [161Tb]Tb-TbCl3

Structure of TbCl3 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 61458

[161Tb]Tb-TbCl3

Also written as [Tb-161]TbCl3

Radionuclide: Tb-161 t½ 9907.2 min
Modality: Therapy
Production route: —
Stage: Preclinical
Syntheses indexed: 2

Radiochemistry methodology Radiolabelling starting material

What it is

Compound class: Radiolanthanide chloride salt (161Tb starting material)
Target / mechanism: —
Clinical application: —
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	custom manifold	—	85-99%	≥99.999%	160Gd2O3 Isoflex, San Francisco, CA, USA	42075874 2026 Pharmaceuticals (Basel) The separation process can be performed with manual fraction collecting even when processing high activity targets - The separation yields of purified 161Tb varied from 85 to 99%, with the activities of 9.9–22.1 GBq
Manual synthesis	custom manifold	—	75-90% decay-corrected	—	[155Tb]TbCl3	34778932 2021 EJNMMI Radiopharm Chem a chemical separation system was designed, built, and introduced into a hot cell - The separation yield resulted in 75–90%, indicating that only 10–25% of terbium-155 activity were lost during separation

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: Isoflex, San Francisco, CA
Typical final purification: —

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Notes

Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 4 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Stage set/updated at stage 39 from PMID 42075874: 'The preparation of 161Tb in a n.c.a. form proceeds, according to the reported data, with high reproducibility and achieves significant activity levels suitable for both preclinical and clinical investigations'.