Tracer library / [212Pb]Pb-MC1L

[212Pb]Pb-MC1L

Also written as [Pb-212]Pb-MC1L

Radionuclide: Pb-212 t½ 638.4 min
Modality: Therapy
Production route: —
Stage: —
Syntheses indexed: 1

Melanoma

What it is

Compound class: DOTA-conjugated cyclic peptide (melanocortin 1 receptor ligand)
Target / mechanism: Melanocortin 1 receptor (MC1R) PMID 31318566
Clinical application: Alpha-particle radioligand therapy for metastatic melanoma via MC1R targeting PMID 31318566
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	HPLC	—	—	DOTA-MC1L	31318566 2019 Mol Pharm 203PbCl2 was dissolved in 0.5 M HCl and 212PbCl2 eluted from 224Ra/212Pb generator

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Notes

Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 2 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty.