Tracer library / [13N]Ammonia

Structure of Ammonia (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 222

[13N]Ammonia

Also written as [13N]Ammonia; [N-13]Ammonia

Radionuclide: N-13 t½ 9.97 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 4

Myocardial perfusion

What it is

Compound class: Inorganic radiolabeled small molecule (ammonia)
Target / mechanism: —
Clinical application: Myocardial perfusion imaging by PET PMID 35478690
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
N100 (13N-NH3 synthesizer) Sumitomo	custom manifold	SPE	—	—	—	27744544 2017 Ann Nucl Med 13N-NH3 was produced using a 13N-NH3 synthesizer N100 (Sumitomo Heavy Industries).
CFN-MPS100 Sumitomo	vendor cassette	—	95-97 not corrected	>95%	10 mM ethanol (aq) in O-16 water target Sigma-Aldrich	35478690 2022 Indian J Nucl Med dedicated multipurpose automated synthesizers termed as MPS-100 - The protocol developed with MPS-100 synthesizer yield (13N)-NH395–97% (EOB) with a synthesis time of around 7 min.
In-house / custom built Laboratory	—	—	—	—	—	35397362 2022 Appl Radiat Isot we developed and validated an Arduino-based device to purifying [13N]NH3 for clinical use
—	—	—	80-90%	—	bombarded water containing 13NO3- and TiCl3	7268053 1981 Radioisotopes A fully automated apparatus for repeated production of 13NH3 from proton-bombarded water has been developed. - 13NH3 can be produced automatically and repeatedly in a radiochemical yield of 80-90% within 10 min from the EOB.

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: Sigma-Aldrich
Typical final purification: —

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Quality control Pharmacopoeial monograph

Ph. Eur. monograph: 1492 Ammonia (13N) injection
USP monograph: Ammonia N 13 Injection long-standing USP-NF radiopharmaceutical monograph; title confirmed on USP's public USP-NF preview page https://doi.usp.org/USPNF/USPNF_M56930_05_01.html, read 2026-09-26; a revision was made official in USP 41 2S on 2018-12-01 per https://www.usp.org/small-molecules/radioactive-articles

AppearancepHRCP TLCRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. Base set per Ph. Eur. 0125 + monograph 1492. Very short half-life -> sterility and part of radionuclidic testing are retrospective (cGRPP PMC7881071). Monograph is OLD (Ph. Eur. 7.0) and under revision — treat test details as provisional.

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with N-13. Compound class inferred from precursor name (not stated outright) -- PMID 35478690: '5 mM of EtOH (aq) as an additive in O-16 water target is used to produce the (13N)-NH3 directly during irradiation'.