Tracers / [13N]Ammonia
[13N]Ammonia
Also written as [13N]Ammonia; [N-13]Ammonia
- Radionuclide
- N-13 t½ 9.97 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 5
What it is
- Compound class
- Inorganic radiolabeled small molecule (ammonia)
- Target / mechanism
- —
- Clinical application
- Myocardial perfusion imaging by PET PMID 35478690
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| N100 (13N-NH3 synthesizer) Sumitomo | custom manifold | SPE | — | — | — | 27744544 2017 Ann Nucl Med 13N-NH3 was produced using a 13N-NH3 synthesizer N100 (Sumitomo Heavy Industries). |
| CFN-MPS100 Sumitomo | vendor cassette | — | 95-97 no | >95% | 10 mM ethanol (aq) in O-16 water target Sigma-Aldrich | 35478690 2022 Indian J Nucl Med dedicated multipurpose automated synthesizers termed as MPS-100 — The protocol developed with MPS-100 synthesizer yield (13N)-NH395–97% (EOB) with a synthesis time of around 7 min. |
| — | — | — | — | — | — | 40279936 2025 Appl Radiat Isot developed and validated a semi-automated purification module to enhance safety, reliability, and efficiency in clinical research settings |
| — | — | — | — | — | — | 35397362 2022 Appl Radiat Isot we developed and validated an Arduino-based device to purifying [13N]NH3 for clinical use |
| — | — | — | 80-90% | — | bombarded water containing 13NO3- and TiCl3 | 7268053 1981 Radioisotopes A fully automated apparatus for repeated production of 13NH3 from proton-bombarded water has been developed. — 13NH3 can be produced automatically and repeatedly in a radiochemical yield of 80-90% within 10 min from the EOB. |
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Get in touchQuality control Pharmacopoeial monograph
- Ph. Eur. monograph
- 1492
- USP monograph
- USP monograph: Ammonia N 13 Injection (long-standing USP-NF radiopharmaceutical monograph)
How this set was arrived at. Base set per Ph. Eur. 0125 + monograph 1492. Very short half-life -> sterility and part of radionuclidic testing are retrospective (cGRPP PMC7881071). Monograph is OLD (Ph. Eur. 7.0) and under revision — treat test details as provisional.
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [13N]Ammonia.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with N-13. Compound class inferred from precursor name (not stated outright) -- PMID 35478690: '5 mM of EtOH (aq) as an additive in O-16 water target is used to produce the (13N)-NH3 directly during irradiation'.