Tracers / [177Lu]Lu-CHX-A''-DTPA-F8
[177Lu]Lu-CHX-A''-DTPA-F8
Also written as [Lu-177]Lu-CHX-A''-DTPA-F8
- Radionuclide
- Lu-177 t½ 9584.6 min
- Modality
- Therapy
- Production route
- —
- Stage
- Reported once
- Syntheses indexed
- 1
What it is
- Compound class
- Antibody-based radioimmunoconjugate (F8 antibody-CHX-A''-DTPA chelator construct)
- Target / mechanism
- Targets the extra domain A (EDA) of fibronectin, an extracellular matrix protein highly abundant in TNBC stroma PMID 41537706
- Clinical application
- Radioligand therapy for triple-negative breast cancer, targeting extracellular matrix (extra domain A of fibronectin) as part of an 89Zr/177Lu theranostic pair PMID 41537706
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | SPE | >95% | — | p-SCN-Bn-CHX-A”-DTPA Macrocyclics | 41537706 2026 Clin Cancer Res F8 at pH 8.5 was incubated with p-SCN-Bn-CHX-A”-DTPA (Macrocyclics #B-355, CAS #157380–45-5) in a 1:6 molar ratio at 37 °C and 300 rpm for 90 minutes. — [177Lu]Lu-CHX-A”-DTPA-F8 (referred to as 177Lu-F8) radiosynthesis yielded > 95% radiochemical conversion at specific activity up to 0.56 MBq/μg |
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Get in touchNotes
Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 41537706. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 41537706: 'p-SCN-Bn-CHX-A”-DTPA (Macrocyclics #B-355, CAS #157380–45-5)'.