Tracers / [131I]I-131-SFMS
[131I]I-131-SFMS
Also written as I-131-SFMS; I-131-SFMs
- Radionuclide
- I-131 t½ 11549 min
- Modality
- Therapy
- Production route
- —
- Stage
- —
- Syntheses indexed
- 1
What it is
- Compound class
- Silk fibroin microspheres (SFMS) embolic agent
- Target / mechanism
- Radioembolic agent for transhepatic artery embolization delivering local radiation via iodinated silk fibroin microspheres PMID 37598140
- Clinical application
- Preclinical (rat model) transhepatic arterial radioembolization for liver cancer PMID 37598140
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | — | >95% | 98.1 ± 0.2% | SFMS (silk fibroin microspheres) Suzhou SIMATECH Biotechnology Co., LTD | 37598140 2023 J Nanobiotechnology 3.5 µL sodium iodide (Na131I, 37 MBq/µL) solution and 50 µL SFMS suspension were added into Iodogen tube successively. At room temperature, Iodogen tube was placed on vortex mixer for 20 min to obtain 131I-labeled SFMS suspension. — the labeling rate > 95% was defined as meeting the requirements of utter iodination |
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Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 2 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 37598140: 'SFMS (silk fibroin microspheres)'.