Tracers / [123I]FP-CIT
[123I]FP-CIT
Also written as [123I]FP-CIT; [I-123]FP-CIT; FP-CIT; I-123 FP-CIT; I-123-FP-CIT
- Radionuclide
- I-123 t½ 792 min
- Modality
- SPECT
- Production route
- —
- Stage
- Approved
- Syntheses indexed
- 8
What it is
- Compound class
- Radioiodinated tropane (cocaine analogue)
- Target / mechanism
- Dopamine transporter (DAT) at presynaptic nigrostriatal dopaminergic terminals PMID 21410815
- Clinical application
- SPECT imaging to assist the diagnosis of parkinsonian syndromes and differentiate dementia with Lewy bodies from Alzheimer's disease PMID 21410815
- Theranostic pair
- —
Regulatory status
- FDA
- 2011, DaTscan, GE Healthcare FDA (Drugs@FDA/openFDA): NDA022454, approved 2011-01-14
- EMA (centralised)
- 2000, DaTSCAN, GE Healthcare EMA medicines register export (2026-09-09): EMEA/H/C/000266, 'Authorised', authorised 27 Jul 2000
- Other approvals
- Celsunax (ioflupane (123I)) — a second, separate EU centralised authorisation for the same substance
- Brand names
- DaTscan / DaTSCAN
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | — | — | — | — | 38848178 2024 J Alzheimers Dis |
| — | — | — | — | — | — | 37629643 2023 Life (Basel) |
| — | — | — | — | — | — | 25710187 2015 J Neural Eng |
| — | — | — | — | — | — | 25304848 2015 Rev Esp Med Nucl Imagen Mol |
| — | — | — | — | — | — | 23401604 2013 J Nucl Med Technol |
| — | — | — | — | — | — | 17704252 2007 J Nucl Med |
| — | — | — | — | — | — | 16000279 2005 J Nucl Med |
| — | — | — | — | — | — | 42231758 2026 Nucl Med Commun |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [123I]FP-CIT.
Get in touchNotes
Added from reverse module search (stage 6); 3 article(s) with I-123. Also seen with I-131[1] (too few articles for own row).