Tracer library / [123I]FP-CIT
Structure of FP-CIT (unlabelled parent compound, from PubChem)
Unlabelled parent compoundPubChem CID 10048368

[123I]FP-CIT

Also written as [123I]FP-CIT; [I-123]FP-CIT; FP-CIT; I-123 FP-CIT; I-123-FP-CIT
Radionuclide
I-123 t½ 792 min
Modality
SPECT
Production route
—
Stage
Approved
Syntheses indexed
0
Parkinsonian syndromes and movement disorders

What it is

Compound class
Radioiodinated tropane (cocaine analogue)
Target / mechanism
Dopamine transporter (DAT) at presynaptic nigrostriatal dopaminergic terminals PMID 21410815
Clinical application
SPECT imaging to assist the diagnosis of parkinsonian syndromes and differentiate dementia with Lewy bodies from Alzheimer's disease PMID 21410815
Theranostic pair
—

Regulatory status

FDA
2011, DaTscan, GE Healthcare FDA (Drugs@FDA/openFDA): NDA022454, approved 2011-01-14
EMA (centralised)
2000, DaTSCAN, GE Healthcare EMA medicines register export (2026-09-09): EMEA/H/C/000266, 'Authorised', authorised 27 Jul 2000
Other approvals
Celsunax (ioflupane (123I)) — a second, separate EU centralised authorisation for the same substance
Brand names
DaTscan / DaTSCAN

Published syntheses

No synthesis has been parsed for this agent yet.

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

  1. REM sleep without atonia thresholds are associated with reduced cardiac MIBG uptake but not with DAT-SPECT binding in probable REM sleep behavior.
    2026 · Sleep Med · Multicentre
  2. Role of Functional Neuroimaging with 123I-MIBG and 123I-FP-CIT in De Novo Parkinson's Disease: A Multicenter Study.
    2023 · Life (Basel) · Retrospective, multicentre
  3. Relationships between neuroimaging biomarkers and glymphatic-system activity in dementia with Lewy bodies.
    2024 · Neurosci Lett · Retrospective
  4. Diagnostic Sensitivity and Symptomatic Relevance of Dopamine Transporter Imaging and Myocardial Sympathetic Scintigraphy in Patients with Dementia with Lewy Bodies.
    2024 · J Alzheimers Dis · Retrospective
  5. A diagnostic strategy for Lewy body disease using DAT-SPECT, MIBG and Combined index.
    2020 · Ann Nucl Med · Retrospective
  6. Parkinson's disease subtypes and their relationship to dementia with Lewy bodies: a comparative neuroimaging analysis based on nigrostriatal degeneration.
    2026 · J Neural Transm (Vienna) · Clinical study
  7. Serum phosphorus levels associated with nigrostriatal dopaminergic deficits in drug-naïve Parkinson's disease.
    2024 · J Neurol Sci · Clinical study
  8. Serial Nigrostriatal Dopaminergic Imaging in Mild Cognitive Impairment With Lewy Bodies, Alzheimer Disease, and Age-Matched Controls.
    2023 · Neurology · Clinical study
  9. Occipital hypometabolism is a risk factor for conversion to Parkinson's disease in isolated REM sleep behaviour disorder.
    2023 · Eur J Nucl Med Mol Imaging · Clinical study
  10. Rapid Eye Movement Sleep Behavior Disorder: Abnormal Cardiac Image and Progressive Abnormal Metabolic Brain Pattern.
    2022 · Mov Disord · Clinical study
Show all 13 clinical studies
  1. Computer-aided diagnosis of Parkinson's disease based on [(123)I]FP-CIT SPECT binding potential images, using the voxels-as-features approach and support vector machines.
    2015 · J Neural Eng · Clinical study
  2. Validation of a standardized normalization template for statistical parametric mapping analysis of 123I-FP-CIT images.
    2007 · J Nucl Med · Clinical study
  3. Clinical testing of an optimized software solution for an automated, observer-independent evaluation of dopamine transporter SPECT studies.
    2005 · J Nucl Med · Clinical study

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph
not verified No Ph. Eur. check is recorded for this entry.
USP monograph
not verified No USP check is recorded for this entry.
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 3 article(s) with I-123. Also seen with I-131[1] (too few articles for own row).
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