Tracers / [68Ga]GaCl3
[68Ga]GaCl3
Also written as [68Ga]GaCl3; [Ga-68]GaCl3; gallium-68 chloride
- Radionuclide
- Ga-68 t½ 67.7 min
- Modality
- PET
- Production route
- Generator / Cyclotron liquid target / Cyclotron solid target
- Stage
- n/a
- Syntheses indexed
- 5
What it is
- Compound class
- Radiometal starting material
- Target / mechanism
- n/a
- Clinical application
- 68Ga chloride solution used to radiolabel 68Ga PET radiopharmaceuticals (not for direct use in patients) EMA EPAR GalliaPharm - https://www.ema.europa.eu/en/medicines/human/EPAR/galliapharm
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- Yes — 2024; GalliaPharm (also GalenVita); Eckert & Ziegler Radiopharma GmbH; EMEA/H/C/006053 EMA medicines register, EPAR GalliaPharm, marketing authorisation issued 2024-08-01 — https://www.ema.europa.eu/en/medicines/human/EPAR/galliapharm
- Other approvals
- —
- Brand names
- GalliaPharm; GalenVita (EU, EMA — 68Ge/68Ga generators)
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | — | 74.8 | 100 | — | 41824275 2026 EJNMMI Radiopharm Chem |
| — | — | SPE | — | 97.89 % | [68Ga]GaCl3 | 38447298 2024 Nucl Med Biol using the FASTLab 2 synthesis module to produce [68Ga]GaCl3 equivalent to a 1.85 GBq generator |
| — | — | SPE | 66 ± 5% | — | 68Zn | 34763197 2022 Nucl Med Biol using a single FASTlab time-list — average radiochemical yields of 66 ± 5% |
| — | — | — | — | — | 68Zn-based solid target | 32056692 2020 Appl Radiat Isot |
| — | — | SPE | — | — | ZnCl2 | 31421441 2019 Nucl Med Biol purified using octanol resin on an automated system |
Precursor
- Common precursor
- 68Ge/68Ga radionuclide generator eluate; or cyclotron production via 68Zn(p,n)68Ga on a liquid target EMA EPAR GalliaPharm - https://www.ema.europa.eu/en/medicines/human/EPAR/galliapharm; PMID 38006491 / DOI 10.1007/978-1-0716-3499-8_5
- Suppliers seen in the literature
- —
- Typical final purification
- SPE / cation exchange
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Get in touchQuality control Pharmacopoeial monograph
- Ph. Eur. monograph
- 2464 (generator-produced); 3109 (accelerator-produced)
- USP monograph
- not verified — the USP-NF monograph index is subscription-only and no public confirmation was found
How this set was arrived at. Starting-material monograph. NB: Ge-68 breakthrough applies to the GENERATOR product (2464); the ACCELERATOR product (3109) instead requires control of Ga-66/Ga-67/Zn-65 and other accelerator-specific radionuclidic impurities. Sterility/endotoxin/appearance still apply.
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [68Ga]GaCl3.
Get in touchNotes
Not a tracer. Listed because cyclotron-produced Ga-68 is a growing production route.