Tracers / [68Ga]Ga-EMP100

[68Ga]Ga-EMP100

Also written as [68Ga]Ga-EMP100; [Ga-68]Ga-EMP100
Radionuclide
Ga-68 t½ 67.71 min
Modality
PET
Production route
Stage
Syntheses indexed
1

What it is

Compound class
Cyclic oligopeptide conjugated to DOTA chelator (c-MET-targeting peptide)
Target / mechanism
c-MET (transmembrane receptor) PMID 37843660
Clinical application
Theranostic pair

Regulatory status

FDA
EMA (centralised)
Other approvals
Brand names

Clinical use

Typical injected activity
Uptake time

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
Elysia-Raytest
vendor cassetteSPE75%, 72%, 75%
no
99.08%, 99.45%, 99.81%EMP100 peptide
Edinburgh Molecular Imaging
37843660
2023 EJNMMI Radiopharm Chem
The automated synthesis of [68Ga]Ga-EMP100 was performed on the GAIA synthesis module (Elysia Raytest, Belgium) — RCY (n.d.c.)GAIA report> 50%75%72%75%

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
USP monograph
AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activityMetal impuritiesGe-68 breakthrough
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with Ga-68.