Tracer library / [68Ga]Ga-DOTA-Z09591

[68Ga]Ga-DOTA-Z09591

Also written as [68Ga]Ga-ATH001; [68Ga]Ga-DOTA-Z09591; [Ga-68]Ga-DOTA-Z09591

Radionuclide: Ga-68 t½ 67.71 min
Modality: PET
Production route: —
Stage: Clinical research
Syntheses indexed: 0

Fibrosis (non-oncologic)

What it is

Compound class: Affibody molecule (DOTA-conjugated Cys-ATH001)
Target / mechanism: Platelet-derived growth factor receptor beta (PDGFRβ) PMID 41471324
Clinical application: PET imaging of PDGFRβ-expressing fibrotic remodeling in post-infarction myocardium PMID 41471324
Theranostic pair: —

Published syntheses

No synthesis has been parsed for this agent yet.

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

Ga-68-Labeled Affibody Molecule-Based Radiopharmaceutical Targeting Platelet Derived Growth Factor Receptor Beta for Detection of Active Fibrosis in Patients with Myocardial Infarction.
2025 · Pharmaceuticals (Basel) · Clinical study · Phase 0

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activityMetal impuritiesGe-68 breakthrough

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with Ga-68. Compound class inferred from precursor name (not stated outright) -- PMID 41471324: 'DOTA-Cys-ATH001'. Stage set/updated at stage 23 from PMID 41471324: '[68Ga]Ga-ATH001 was successfully developed and validated for phase 0 clinical study.'. | Stage 30 (2026-09-18): Stage was 'phase 0 clinical study'; normalised to 'Clinical research', original wording kept here.