Tracers / [68Ga]Ga-DOTA-ECL1i
[68Ga]Ga-DOTA-ECL1i
Also written as DOTA-ECL1i; Ga-68 DOTA-ECL1i; Ga-68-DOTA-ECL1i
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 2
What it is
- Compound class
- DOTA-conjugated peptide (CCR2-targeting inverso peptide)
- Target / mechanism
- CCR2 (C-C motif chemokine receptor 2) allosteric antagonist binding PMID 36729317
- Clinical application
- PET imaging of CCR2 expression in inflammatory/fibrotic and cardiovascular conditions and cancer: pulmonary fibrosis, heart injury, abdominal aortic aneurysm inflammation, atherosclerosis, head and neck cancer PMID 36729317
- Theranostic pair
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Regulatory status
- FDA
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- EMA (centralised)
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- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | SPE | 66.69% no | 100% | DOTA-ECL1i piCHEM, Raaba-Grambach, Austria | 36729317 2023 EJNMMI Radiopharm Chem the Scintomics GRP® module — an optimal radiochemical yield (66.69%) |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | SPE | 66.69% no | 100% | DOTA-ECL1i piCHEM, Raaba-Grambach, Austria | 36729317 2023 EJNMMI Radiopharm Chem Scinotmics GRP® module (Germany) — obtaining an optimal radiochemical yield (66.69%) |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [68Ga]Ga-DOTA-ECL1i.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with Ga-68. Compound class inferred from precursor name (not stated outright) -- PMID 36729317: 'DOTA-ECL1i was prepared in 10–20–30–40–50 μg aliquots from the stock solution (200 μg/mL)'.