Tracer library / [68Ga]Ga-DOTA-CCK-66
[68Ga]Ga-DOTA-CCK-66
Also written as DOTA-CCK-66; Ga-68 DOTA-CCK-66; Ga-68-DOTA-CCK-66
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- Clinical research
- Syntheses indexed
- 2
What it is
- Compound class
- DOTA-conjugated minigastrin analog peptide (CCK2 receptor-targeting)
- Target / mechanism
- Cholecystokinin-2 receptor (CCK2R) targeting peptide PMID 37945383
- Clinical application
- PET/CT imaging of medullary thyroid cancer patients (proof-of-concept) PMID 37945383
- Theranostic pair
- [177Lu]Lu-DOTA-CCK-66
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | none | — | >98% | DOTA-CCK-66 Chinese Peptide Co., Ltd., Hangzhou, China | 40963930 2025 Theranostics 30 µg of precursor (prepared at a concentration of 1 µg/µL) was added to 110 µL of 1.5 M sodium acetate (NaOAc) solution, followed by the addition of 1 mL of [68Ga]GaCl3 eluate |
| Manual synthesis | — | none | — | >95% | DOTA-CCK-66 | 39392495 2025 Eur J Nucl Med Mol Imaging 68Ga-labeling of DOTA-CCK-66 was completed at 90 °C for 5 min. |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- Chinese Peptide Co., Ltd.
- Typical final purification
- —
Need this precursor?We can point you to suppliers for [68Ga]Ga-DOTA-CCK-66, or handle the enquiry for you.
Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [68Ga]Ga-DOTA-CCK-66.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with Ga-68. Also seen with Lu-177[1] (too few articles for own row). Compound class inferred from precursor name (not stated outright) -- PMID 37945383: 'DOTA-CCK-66 (DOTA-γ-glu-PEG3-Trp-(N-Me)Nle-Asp-1-Nal-NH2, PEG: polyethylene glycol)'. Stage set/updated at stage 23 from PMID 37945383: 'a proof-of-concept clinical investigation of [68Ga]Ga-DOTA-CCK-66 was completed'. | Stage 30 (2026-09-18): Stage was 'proof-of-concept clinical investigation'; normalised to 'Clinical research', original wording kept here.