Tracers / [68Ga]Ga-DOTA-CCK-66
[68Ga]Ga-DOTA-CCK-66
Also written as DOTA-CCK-66; Ga-68 DOTA-CCK-66; Ga-68-DOTA-CCK-66
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- proof-of-concept clinical investigation
- Syntheses indexed
- 5
What it is
- Compound class
- DOTA-conjugated minigastrin analog peptide (CCK2 receptor-targeting)
- Target / mechanism
- Cholecystokinin-2 receptor (CCK2R) targeting peptide PMID 37945383
- Clinical application
- PET/CT imaging of medullary thyroid cancer patients (proof-of-concept) PMID 37945383
- Theranostic pair
- <a href="/tracers/lu177-dotacck66/">lu177-dotacck66</a>
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | none | — | >98% | DOTA-CCK-66 Chinese Peptide Co., Ltd., Hangzhou, China | 40963930 2025 Theranostics 30 µg of precursor (prepared at a concentration of 1 µg/µL) was added to 110 µL of 1.5 M sodium acetate (NaOAc) solution, followed by the addition of 1 mL of [68Ga]GaCl3 eluate |
| Manual synthesis | — | none | — | >95% | DOTA-CCK-66 | 39392495 2025 Eur J Nucl Med Mol Imaging 68Ga-labeling of DOTA-CCK-66 was completed at 90 °C for 5 min. |
| — | — | — | — | — | DOTA-CCK-66 | 37945383 2024 J Nucl Med |
| — | — | — | — | — | DOTA-MGS5 | 30530828 2019 J Nucl Med |
| — | — | — | — | — | — | 39093043 2024 Clin Nucl Med |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [68Ga]Ga-DOTA-CCK-66.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with Ga-68. Also seen with Lu-177[1] (too few articles for own row). Compound class inferred from precursor name (not stated outright) -- PMID 37945383: 'DOTA-CCK-66 (DOTA-γ-glu-PEG3-Trp-(N-Me)Nle-Asp-1-Nal-NH2, PEG: polyethylene glycol)'. Stage set/updated at stage 23 from PMID 37945383: 'a proof-of-concept clinical investigation of [68Ga]Ga-DOTA-CCK-66 was completed'.