Tracer library / [68Ga]Ga-DO3A-VS-Cys40-Tuna-2
[68Ga]Ga-DO3A-VS-Cys40-Tuna-2
Also written as [68Ga]Ga-DO3A-Tuna-2; [68Ga]Ga-DO3A-VS-Cys40-S01-GCG; [68Ga]Ga-DO3A-VS-Cys40-Tuna-2; [Ga-68]Ga-DO3A-VS-Cys40-Tuna-2
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 1
What it is
- Compound class
- DO3A-conjugated peptide analogue (glucagon receptor-binding peptide, DO3A-VS-Cys40-Tuna-2)
- Target / mechanism
- Glucagon receptor (GCGR) binding PMID 32752075
- Clinical application
- PET microdosing study for quantification of GCGR occupancy by an anti-diabetic drug in humans PMID 32752075
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Modular-Lab PharmTracer Eckert & Ziegler | vendor cassette | SPE | 45.2 ± 2.5% not corrected | 98.9 ± 0.6% | DO3A-VS-Cys40-Tuna-2 Sanofi | 32752075 2020 Pharmaceuticals (Basel) Modular-Lab PharmTrace (Eckert & Ziegler, Eurotope, Germany) - The non-decay-corrected radiochemical yield was 45.2 ± 2.5% (n = 3, process validation) |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- Sanofi
- Typical final purification
- —
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [68Ga]Ga-DO3A-VS-Cys40-Tuna-2.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with Ga-68. Compound class inferred from precursor name (not stated outright) -- PMID 32752075: 'The active pharmaceutical ingredient starting material DO3A-VS-Cys40-Tuna-2 (GMP-grade) was provided by Sanofi Aventis.'. | Stage 28: added indication(s) end-receptor-occupancy from consolidated missing-rubric review.