Tracers / [68Ga]Ga-citrate
[68Ga]Ga-citrate
Also written as [68Ga]Ga-Citrate; [Ga-68]Ga-Citrate; Citrate; Ga-68 Citrate; Ga-68-Citrate
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 6
What it is
- Compound class
- Gallium-68 citrate complex (small molecule metal-ion radiopharmaceutical)
- Target / mechanism
- —
- Clinical application
- PET imaging of inflammation/infection of musculoskeletal, gastrointestinal, respiratory, and cardiovascular systems PMID 35164258
- Theranostic pair
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Regulatory status
- FDA
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- EMA (centralised)
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- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
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- Uptake time
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Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| miniAllinOne Trasis | custom manifold | SPE | 95.8 ± 0.8% yes | >99% | sodium citrate solution (136 mM) | 35164258 2022 Molecules miniAllInOne® (Trasis) — with a radiochemical yield of 95.8 ± 0.8 % (n= 32) decay corrected to the SOE (start of elution) |
| iMiDEV PMB-Alcen | vendor cassette | SPE | 90.1 ± 3.1% yes | 98.7 ± 1.2% | sodium citrate solution (136 mM) | 35164258 2022 Molecules iMiDEV™ (PMB-Alcen) — [68Ga]Ga-citrate on the R1 was obtained in 90.1 ± 3.1% yield when filled with PS-H+ cation exchanger |
| — | — | — | — | — | — | 23522791 2013 Appl Radiat Isot |
| — | — | HPLC | >98% | — | — | 32316906 2021 Curr Radiopharm using the Scintomics automated synthesis system (Scintomics GmbH GRP module 4V) — The labelling efficiency was found to be >98%. |
| — | — | — | — | greater than 99% | — | 23764941 2013 Nucl Med Commun A commercially available synthesis module was used to perform 10 syntheses — an average yield of 768 ± 31 MBq (mean ± SD) within 10 min |
| — | — | — | 64.1+/-6.0% | higher than 98% | — | 19424101 2009 Nucl Med Commun using a commercial 68Ga-labelling module — the radiochemical yield was 64.1+/-6.0% (mean+/-standard deviation) |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); weak UV chromophore (sugar/simple ion/short-chain acid) -> conductometric detection (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [68Ga]Ga-citrate.
Get in touchNotes
Added from reverse module search (stage 6); 4 article(s) with Ga-68. Compound class inferred from precursor name (not stated outright) -- PMID 35164258: 'the 136 mM sodium citrate solution in NaCl 0.9%'.