Tracer library / [68Ga]Ga-citrate
[68Ga]Ga-citrate
Also written as [68Ga]Ga-Citrate; [Ga-68]Ga-Citrate; Citrate; Ga-68 Citrate; Ga-68-Citrate
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 4
What it is
- Compound class
- Gallium-68 citrate complex (small molecule metal-ion radiopharmaceutical)
- Target / mechanism
- Non-specific mechanisms including transferrin binding, lactoferrin and siderophore binding, vascular permeability PMID 32316906
- Clinical application
- PET imaging of inflammation/infection of musculoskeletal, gastrointestinal, respiratory, and cardiovascular systems PMID 35164258
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| miniAllinOne Trasis | custom manifold | SPE | 95.8 ± 0.8% decay-corrected | >99% | sodium citrate solution (136 mM) | 35164258 2022 Molecules miniAllInOne® (Trasis) - with a radiochemical yield of 95.8 ± 0.8 % (n= 32) decay corrected to the SOE (start of elution) |
| iMiDEV PMB-Alcen | vendor cassette | SPE | 90.1 ± 3.1% decay-corrected | 98.7 ± 1.2% | sodium citrate solution (136 mM) | 35164258 2022 Molecules iMiDEV™ (PMB-Alcen) - [68Ga]Ga-citrate on the R1 was obtained in 90.1 ± 3.1% yield when filled with PS-H+ cation exchanger |
| Scintomics GRP 4V Scintomics | — | HPLC | >98% | — | — | 32316906 2021 Curr Radiopharm using the Scintomics automated synthesis system (Scintomics GmbH GRP module 4V) - The labelling efficiency was found to be >98%. |
| — | — | — | 64.1+/-6.0% | >98% | — | 19424101 2009 Nucl Med Commun using a commercial 68Ga-labelling module - the radiochemical yield was 64.1+/-6.0% (mean+/-standard deviation) |
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); weak UV chromophore (sugar/simple ion/short-chain acid) -> conductometric detection (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
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Get in touchNotes
Added from reverse module search (stage 6); 4 article(s) with Ga-68. Compound class inferred from precursor name (not stated outright) -- PMID 35164258: 'the 136 mM sodium citrate solution in NaCl 0.9%'.