Tracer library / [18F]UCB-H

Structure of UCB-H (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 86302304

[18F]UCB-H

Also written as [18F]UCB-H; [F-18]UCB-H

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 1

What it is

Compound class: iodonium salt-derived 18F-labeled small molecule ligand
Target / mechanism: synaptic vesicle glycoprotein 2A (SV2A) PMID 27598384
Clinical application: clinical research on a range of neurological pathologies through imaging of SV2A PMID 27598384
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
—	—	—	34 ± 2% not corrected	—	pyridyl(4-methoxyphenyl)iodonium salt	27598384 2016 J Med Chem

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 27598384: 'the straightforward synthesis of a stable pyridyl(4-methoxyphenyl)iodonium salt and its [18F] radiolabeling'.