Tracers / [18F]tGBP4F
[18F]tGBP4F
Also written as [18F]tGBP4F; [F-18]tGBP4F
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 2
What it is
- Compound class
- Gabapentin derivative (fluorinated gabapentinoid)
- Target / mechanism
- Ligand for the α2δ subunit of voltage-dependent calcium channels PMID 37732236
- Clinical application
- Brain PET imaging of α2δ receptors PMID 37732236
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX2 N GE HealthCare | — | HPLC | 4.3 ± 2.2 no | >99% | precursor 1a | 37947793 2023 ACS Chem Neurosci automated radiosynthesis methods were developed using a GE TRACERlab FX2N two-reactor synthesis module — non-decay corrected radiochemical yield: 4.3 ± 2.2 %, n = 13 |
| TRACERlab FX2 N GE HealthCare | — | HPLC | 4.3 ± 2.2 % no | >99% | isomerically pure precursor 1a | 37732236 2023 bioRxiv automated radiosynthesis methods were developed using a GE TRACERlab FX2N two-reactor synthesis module — non-decay corrected radiochemical yield: 4.3 ± 2.2 %, n = 13 |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]tGBP4F.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with F-18.