Tracer library / [18F]TFB
Structure of Tetrafluoroborate (unlabelled parent compound, from PubChem)
Unlabelled parent compoundPubChem CID 26255

[18F]TFB

Also written as [18F]BF4; [18F]BF4-; [18F]Tetrafluoroborate; [18F]TFB; [F-18]BF4; [F-18]Tetrafluoroborate; [F-18]TFB
Radionuclide
F-18 t½ 109.7 min
Modality
PET
Production route
Cyclotron liquid target
Stage
Clinical research
Syntheses indexed
3
Thyroid function and NIS expressionReporter gene imaging

What it is

Compound class
Inorganic anion
Target / mechanism
Sodium/iodide symporter (NIS) substrate PMID 29080017 / DOI 10.1186/s13550-017-0337-5
Clinical application
Imaging of NIS expression (thyroid; NIS as a reporter gene) PMID 29080017 / DOI 10.1186/s13550-017-0337-5
Theranostic pair
—

Regulatory status

FDA
No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=fluorotetrafluoroborate
EMA (centralised)
—
Other approvals
—
Brand names
—

Clinical use

Typical injected activity
333-407 MBq in healthy volunteers PMID 29080017 / DOI 10.1186/s13550-017-0337-5
Uptake time
Dynamic + whole-body static PET/CT over 4 h post-injection (dosimetry) PMID 29080017 / DOI 10.1186/s13550-017-0337-5

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
—
Synthra
custom manifoldSPE41.0%
range 30.2–56.0%
98.4 ± 1.5%boron trifluoride-methanol complex
Sigma-Aldrich
36512196
2022 EJNMMI Radiopharm Chem
customised SYNTHRA module (Synthra GmbH, Germany) - These conditions ... provided RCY 41.0% (range 30.2–56.0%) and Am in the range of 33.9–216.7 GBq/µmol at EOS
TRACERlab FX FN
GE HealthCare
vendor cassetteSPE50
26
98
1
boron trifluoride acetonitrile complex
Sigma-Aldrich
36512196
2022 EJNMMI Radiopharm Chem
TRACERLAB FXFN (GE Healthcare) - FXFN (n = 5)CH3CN1/30035 (30)50(26)98 (1)39.8 (2.1–99.3)1.13
——SPE14.2% ± 1.2%97.5% ± 0.95%15-Crown-5 and boron trifluoride diethyl…15-Crown-5 and boron trifluoride diethyl etherate
Sigma-Aldrich
36458201
2022 Mol Ther Oncolytics

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

  1. Incremental diagnostic value of [18F]tetrafluoroborate PET-CT compared to [131I]iodine scintigraphy in recurrent differentiated thyroid cancer.
    2020 · Eur J Nucl Med Mol Imaging · Retrospective

Precursor

Common precursor
—
Suppliers seen in the literature
—
Cited suppliers in indexed syntheses
Sigma-Aldrich
Typical final purification
SPE

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph
not verified No Ph. Eur. check is recorded for this entry.
USP monograph
not verified No USP check is recorded for this entry.
AppearancepHRCP HPLCRCP TLCHPLC cond.Radionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary); STAGE 17.4 recheck by compound class ('Inorganic anion'): HPLC UV -> HPLC cond. (tetrafluoroborate (BF4-) -- a simple inorganic anion with no UV chromophore at all, same category as fluoride/chloride/phosphate/sulfate)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Labelled by isotopic exchange on boron rather than by nucleophilic substitution.
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