Tracers / [18F]TFB
[18F]TFB
Also written as [18F]BF4; [18F]BF4-; [18F]Tetrafluoroborate; [18F]TFB; [F-18]BF4; [F-18]Tetrafluoroborate; [F-18]TFB
- Radionuclide
- F-18 t½ 109.7 min
- Modality
- PET
- Production route
- Cyclotron liquid target
- Stage
- Clinical research
- Syntheses indexed
- 4
What it is
- Compound class
- Inorganic anion
- Target / mechanism
- Sodium/iodide symporter (NIS) substrate PMID 29080017 / DOI 10.1186/s13550-017-0337-5
- Clinical application
- Imaging of NIS expression (thyroid; NIS as a reporter gene) PMID 29080017 / DOI 10.1186/s13550-017-0337-5
- Theranostic pair
- —
Regulatory status
- FDA
- No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=fluorotetrafluoroborate
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- 333-407 MBq in healthy volunteers PMID 29080017 / DOI 10.1186/s13550-017-0337-5
- Uptake time
- Dynamic + whole-body static PET/CT over 4 h post-injection (dosimetry) PMID 29080017 / DOI 10.1186/s13550-017-0337-5
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — Synthra | custom manifold | SPE | 41.0% (range 30.2–56.0%) | 98.4 ± 1.5% | boron trifluoride-methanol complex Sigma-Aldrich | 36512196 2022 EJNMMI Radiopharm Chem customised SYNTHRA module (Synthra GmbH, Germany) — These conditions ... provided RCY 41.0% (range 30.2–56.0%) and Am in the range of 33.9–216.7 GBq/µmol at EOS |
| TRACERlab FX FN GE HealthCare | vendor cassette | SPE | 50 (26) | 98 (1) | boron trifluoride acetonitrile complex Sigma-Aldrich | 36512196 2022 EJNMMI Radiopharm Chem TRACERLAB FXFN (GE Healthcare) — FXFN (n = 5)CH3CN1/30035 (30)50(26)98 (1)39.8 (2.1–99.3)1.13 |
| — | — | SPE | 14.2% ± 1.2% | 97.5% ± 0.95% | 15-Crown-5 and boron trifluoride diethyl etherate Sigma-Aldrich | 36458201 2022 Mol Ther Oncolytics |
| — | — | — | — | — | BF4− | 32248325 2020 Eur J Nucl Med Mol Imaging |
Need this precursor?We can point you to suppliers for [18F]TFB, or handle the enquiry for you.
Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary); STAGE 17.4 recheck by compound class ('Inorganic anion'): HPLC UV -> HPLC cond. (tetrafluoroborate (BF4-) -- a simple inorganic anion with no UV chromophore at all, same category as fluoride/chloride/phosphate/sulfate)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]TFB.
Get in touchNotes
Labelled by isotopic exchange on boron rather than by nucleophilic substitution.