Tracer library / [18F]SMBT-1

Structure of SMBT-1 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 156481434

[18F]SMBT-1

Also written as [18F]SMBT-1; [F-18]SMBT-1; F-18 SMBT-1; SMBT-1

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 0

Neuroinflammation Parkinsonian syndromes and movement disorders

What it is

Compound class: quinoline-based tosylate precursor derivative (THK-5475 scaffold)
Target / mechanism: Reactive astrogliosis / astrocyte imaging marker PMID 41437980
Clinical application: PET imaging of reactive astrocytes in Parkinson's disease PMID 41437980
Theranostic pair: —

Published syntheses

No synthesis has been parsed for this agent yet.

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

Automated radiosynthesis and clinical experience of [18F]SMBT-1 PET imaging for in vivo evaluation of reactive astrocyte in Parkinson's disease: a pilot study.
2025 · Front Nucl Med · Clinical study

Need this precursor?We can point you to suppliers for [18F]SMBT-1, or handle the enquiry for you.

Get in touch

Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

Setting up quality control?We can help you scope the equipment needed to release [18F]SMBT-1.

Get in touch

Notes

Added from reverse module search (stage 6); 3 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 41437980: '2.0 mg of the tosylate precursor,(S)-(2-methylpyrid-5-yl)-6-{[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy] propoxy}quinoline (THK-5475, Hebei Sundia MediTech, China)'.