Tracers / [18F]SMBT-1
[18F]SMBT-1
Also written as [18F]SMBT-1; [F-18]SMBT-1; F-18 SMBT-1; SMBT-1
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 1
What it is
- Compound class
- quinoline-based tosylate precursor derivative (THK-5475 scaffold)
- Target / mechanism
- Reactive astrogliosis / astrocyte imaging marker PMID 41437980
- Clinical application
- PET imaging of reactive astrocytes in Parkinson's disease PMID 41437980
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Synthra RNplus Synthra | — | HPLC+SPE | 36.56 ± 11.55% yes | >95% | THK-5475 tosylate precursor Hebei Sundia MediTech, China | 41437980 2025 Front Nucl Med Automated synthesis of [18F]SMBT-1 was performed using the Synthra RNplus synthesizer module (Synthra GmbH, Germany). — [18F]SMBT-1 was obtained with an average decay-corrected radiochemical yield of 36.56 ± 11.55% and molar activity as 396 Gbq/μmol at the end of synthesis (n = 7). |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
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Get in touchNotes
Added from reverse module search (stage 6); 3 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 41437980: '2.0 mg of the tosylate precursor,(S)-(2-methylpyrid-5-yl)-6-{[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy] propoxy}quinoline (THK-5475, Hebei Sundia MediTech, China)'.