Tracers / [18F](E)-PSS232

[18F](E)-PSS232

Also written as [18F](E)-PSS232
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
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Stage
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Syntheses indexed
1
CNS receptor and transporter imagingRadiochemistry methodology

What it is

Compound class
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Target / mechanism
metabotropic glutamate receptor subtype 5 (mGlu5) PMID 28948638
Clinical application
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Theranostic pair
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Regulatory status

FDA
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EMA (centralised)
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Other approvals
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Brand names
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Clinical use

Typical injected activity
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Uptake time
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Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
——HPLC40 ± 2%
yes
>95%mesylate precursor28948638
2018 J Labelled Comp Radiopharm
using a commercial GE TRACERlab™ FX-FN synthesizer for routine production and distribution to nearby satellite clinics — provided [18 F]2a with a radiochemical yield of 40 ± 2% (decay corrected, n = 5) at the end of synthesis

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
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USP monograph
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AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18.