Tracer library / [18F](E)-PSS232
[18F](E)-PSS232
Also written as [18F](E)-PSS232
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 1
What it is
- Compound class
- oxime-based small molecule radiotracer (fluoroethoxypropyl oxime analogue of cyclohexenone)
- Target / mechanism
- metabotropic glutamate receptor subtype 5 (mGlu5) PMID 28948638
- Clinical application
- Brain PET imaging for neuropsychiatric disorders involving mGlu5 PMID 28948638
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX FN GE HealthCare | — | HPLC | 40 ± 2% decay-corrected | >95% | mesylate precursor | 28948638 2018 J Labelled Comp Radiopharm using a commercial GE TRACERlab™ FX-FN synthesizer for routine production and distribution to nearby satellite clinics - provided [18 F]2a with a radiochemical yield of 40 ± 2% (decay corrected, n = 5) at the end of synthesis |
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F](E)-PSS232.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with F-18.