Tracer library / [18F]OP-801

[18F]OP-801

Also written as [18F]OP-801; [F-18]OP-801

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Clinical research
Syntheses indexed: 1

Neuroinflammation Amyotrophic lateral sclerosis / motor neuron disease

What it is

Compound class: PAMAM-G4 dendrimer conjugate
Target / mechanism: Selectively taken up by reactive microglia and macrophages PMID 37310119
Clinical application: PET imaging of reactive microglia and macrophages in neuroinflammatory diseases PMID 37310119
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX FN GE HealthCare	custom manifold	HPLC+SPE	6.89% decay-corrected	99%	PAMAM-G4-OH alkyne10 dendrimer precursor…PAMAM-G4-OH alkyne10 dendrimer precursor and 3-azidopropyl-4-methylbenzenesulfonate Snapdragon Chemistry	37310119 2023 ACS Chem Neurosci All chemistry was performed on a TRACERlab FX–FN synthesis module (GE) with an adjacent custom synthesis platform (built in-house) and a remote control HPLC column selector (Cheminert 6 port, VICI) - average of 6.89% (SD 2.23) decay corrected radiochemical yield

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: Snapdragon Chemistry
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 37310119: 'polyamidoamine generation 4 hydroxyl alkyne (10) dendrimer (PAMAM-G4-OH alkyne10)'. Stage set/updated at stage 23 from PMID 37310119: 'a phase 1/2 clinical trial (NCT05395624) for first-in-human imaging in healthy controls and patients with amyotrophic lateral sclerosis is underway'. | Stage 28: added indication(s) neu-als from consolidated missing-rubric review. | Stage 30 (2026-09-18): Stage was 'phase 1/2 clinical trial (first-in-human)'; normalised to 'Clinical research', original wording kept here.