Tracer library / [18F]NOTA-ABY-030

[18F]NOTA-ABY-030

Also written as [18F]NOTA-ABY-030; [F-18]NOTA-ABY-030

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 1

Head and neck cancer

What it is

Compound class: small biologic targeting vector (Affibody) labeled with [18F]NOTA via aluminum fluoride
Target / mechanism: Epidermal Growth Factor Receptor (EGFR) PMID 42423882
Clinical application: Head and Neck Squamous Cell Carcinoma (HNSCC) PMID 42423882
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
FASTlab GE HealthCare	—	—	47 ± 10%	>90%	NOTA-ABY-030	42423882 2026 Mol Imaging Biol GE HealthCare FASTlab cassette-based automated radiosynthesis system - radiochemical yield of 47 ± 10% (n = 3)

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18.