Tracer library / [18F]MIPS15692

[18F]MIPS15692

Also written as [18F]MIPS15692; [F-18]MIPS15692
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
Preclinical
Syntheses indexed
1
Neuroinflammation

What it is

Compound class
—
Target / mechanism
MER tyrosine kinase (MERTK) PMID 34563964
Clinical application
Neuroinflammatory disease, specifically multiple sclerosis (MS) PMID 34563964
Theranostic pair
—

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
iPHASE FlexLab
iPHASE Technologies
——2.45 ± 0.85%
decay-corrected
>99%—34563964
2021 Eur J Med Chem
[18F]MIPS15692 was synthesized using an automated iPHASE FlexLab module - the decay-corrected radiochemical yields (RCYs) were determined as 2.45 ± 0.85%

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph
not verified No Ph. Eur. check is recorded for this entry.
USP monograph
not verified No USP check is recorded for this entry.
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18.
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