Tracer library / [18F]mG4P027

[18F]mG4P027

Also written as [18F]mG4P027; [F-18]mG4P027

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 1

CNS receptor and transporter imaging

What it is

Compound class: N-(4-chloro-3-(((fluoro-18F)methyl-d2)thio)phenyl)picolinamide
Target / mechanism: metabotropic glutamate receptor 4 (mGluR4) PMID 37496513
Clinical application: —
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX2 N GE HealthCare	custom manifold	HPLC	22% decay-corrected	>99%	compound 1 (di-tosylate) and compound 4…compound 1 (di-tosylate) and compound 4 (thiophenol precursor)	37496513 2023 iRadiology GE TRACERlab FX2N platform - produced in approximately 22% radiochemical yield (decay corrected) within 120 min

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18. Stage set/updated at stage 39 from PMID 37496513: 'Our previous in vitro and in vivo evaluations have demonstrated that this tracer is promising for further translational studies.'.